Effect of clonidine in total sedative agents use in the intensive care unit

Not Applicable

• Conditions: Mechanically ventilated patients in the intensive care unit.; Diseases of the respiratory system; J00-J99

• Registration Number: IRCT2012102910178N3
• Lead Sponsor: shahid beheshti university of medical sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

all patients on mechanical ventilation
Exclusion criteria:mechanical ventilation less than 3 days; sepsis; volume depletion; second or third degree atrioventricular node block; GFR < 15 ml/min; hepatic failure (Child Pough score: severe); GCS < 8; use of clonidine during past month

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Total sedative agents use including opiods, midazolam, other benzodiazepines and propofol. Timepoint: Daily. Method of measurement: Total daily dose.

Secondary Outcome Measures

Name	Time	Method
Clonidine blood level. Timepoint: day 4 and 7. Method of measurement: ELisa kit.;Duration of mechanical ventilation. Timepoint: Daily. Method of measurement: Daily.;Duration of ICU LOS. Timepoint: Daily. Method of measurement: Daily.