Effects of Resistance Training in People Living With HIV/AIDS
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 49
- 试验地点
- 1
- 主要终点
- Change in Cognitive Function
研究概览
简要总结
The aim of this study will be to verify effects of resistance training in people living with HIV/AIDS.
详细描述
The aim of this study was verify effects of resistance training in cognitive function, body composition and biochemical parameters of inflammation and oxidative stress in people living with HIV/AIDS. The sample was composed by patients with HIV/AIDS of both sexes. The patients were randomized in two groups, a exercise group (EG), which was receive intervention with eight weeks of resistance training, and a control group (CG), that was not to do exercise. The cognitive function was analyzed with Stroop Test and Trail Test; body composition was evaluated by bioimpedance; blood tests was use to analyze biochemical parameters of inflammation and oxidative stress. For statistical analysis was used ANOVA of two factors for repeated measurements, having the (EG and PG) group and the time (pre and post exercise). Level of significance adopted was P < 0,05.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
盲法说明
Blood collections and subsequent analyzes were done blindly.
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnostic for HIV/AIDS.
- •Clinical condition and viral count stabilized.
- •Have been using (HAART) for 6 months or more.
- •Not have participated in physical exercise programs in six months before beginning of study.
- •Not have muscle or joint injuries that make it impossible to practice physical activity.
- •Not be pregnant.
排除标准
- •Not attending more than 15% of the intervention sessions or visits to the laboratory.
- •Aggravation of the disease.
- •Stick to a physical activity program in addition to that offered by the study.
研究组 & 干预措施
Exercise group
Exercise group was resistance training three times per week, during 45 to 60 minutes per day. Training program was composed by bench press, leg press 45°, lat pulldown, knee extension, dumbbell lateral raise, horizontal leg curl, triceps pulldown, seated calf raise, biceps curls and abdominal. Participants should complete 3 series with 8-12 repetitions of each exercise, which was supervised by trained research personnel. There were 60 seconds of interval between series and exercises were separated by a 120 seconds recovery period.
干预措施: Exercise group (Other)
Control group
Control group was not do any exercise during intervention period. Participants was asked to keep their habitual routine until finish the final evaluations.
结局指标
主要结局
Change in Cognitive Function
时间窗: Baseline and eight weeks
Victoria Stroop, Castro Cunha \& Martins Stroop and Trail Test were performed at baseline and after eight weeks of intervention in both groups (EG and CG). Blood will be collected and brain-derived neurotrophic factor (BDNF) will be measured by Enzyme-Linked Immunosorbent Assay Method (Human - ELISA Kit) at baseline and after eight weeks of intervention in both groups (EG and CG).
次要结局
- CD4 / CD8(Baseline and eight weeks)
- Concentration of Inflammatory markers(Baseline and eight weeks)
- Health cellular(Baseline and eight weeks)
研究者
Ademar Avelar de Almeida Junior
Principal Investigator
State University of Maringá