A study to compare the effect of a special resveratrol-based nanofiber film placed in gum pockets, along with routine dental cleaning, in patients with long-term gum disease.
Phase 2
Not yet recruiting
- Conditions
- Chronic periodontitis
- Registration Number
- CTRI/2025/05/086178
- Lead Sponsor
- Maria sharon V
- Brief Summary
This randomized controlled clinical trial aims to evaluate the effectiveness of **electrospun resveratrol-loaded nanofibers** as a local drug delivery system when used as an adjunct to **scaling and root planing (SRP)** in patients with **chronic periodontitis**. Participants will be divided into two groups: one receiving SRP with resveratrol nanofiber application, and the other receiving SRP only . The study will assess improvements in **probing pocket depth (PPD)** and **clinical attachment level (CAL)** as primary outcomes, along with changes in **bleeding on probing (BOP)**, as secondary outcome. Assessments will be conducted at baseline, 1 month and 3 months.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
- Adults aged 25 to 60 years 2.
- presence of greater than or equal to 20 teeth 3.
- Probing depth greater than or equal to 5mm in at least 4 sites 4.
- Diagnosed with chronic periodontitis.
Exclusion Criteria
- 1.Systemic illness 2.
- Antibiotics or periodontal treatment in past 6 months 3.Pregnancy/lactation 4.Allergy to resveratrol.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method eduction in probing pocket depth (PPD) Baseline, 1 month and 3 months - Gain in clinical attachment level (CAL) Baseline, 1 month and 3 months
- Secondary Outcome Measures
Name Time Method Bleeding on probing Bleeding on probing - Baseline, !month and 3 months
Trial Locations
- Locations (1)
Saveetha dental college and hospitals
🇮🇳Chennai, TAMIL NADU, India
Saveetha dental college and hospitals🇮🇳Chennai, TAMIL NADU, IndiaDR Maria Sharon velrajPrincipal investigator08124448902152305002.sdc@saveetha.com