NL-OMON48499CompletedNot Applicable
Handheld Laser Speckle Contrast Imaging Device for optical microcirculatory perfusion imaging: Clinical, therapeutic and pathophysiological implications for adult- and paediatric psoriasis. - Handheld Laser Speckle Contrast Imaging in psoriasis.
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 19
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Ages
- 18 to 99 (—)
Inclusion Criteria
- •Cohort 1 (8 patients):
- •To enter into this study patients must meet the following criteria:
- •* * 18 years of age.
- •* Patients with a diagnosis of unstable plaque psoriasis according to a dermatologist.
- •* Patients on topical treatment, who are not eligible or willing to receive systemic anti-psoriatic treatment.
- •* Patients must be willing to discontinue their topical treatment on one body area for a maximum of eight weeks.
- •* Patients must be willing to give a written informed consent.
- •* Patients must be able to adhere to the visit schedule.;Cohort 2 (8 patients):
- •To enter into this study patients must meet the following criteria:
- •* * 18 years of age.
- •* Patients with a diagnosis of plaque psoriasis according to a dermatologist.
- •* Patients who are on topical treatment.
- •* * two clinically visible plaques with a minimal diameter of three centimetres.
- •* Patients must be willing to discontinue topical treatment of two plaques for respectively two and a maximum of ten weeks.
- •* Patients must be able to adhere to the visit schedule.
- •* If applicable: patients must be willing to switch topical therapy for one psoriasis plaque to clobetasol ointment for a maximum of eight weeks.
- •* Patients must be willing to undergo six skin biopsies.
- •* Patients must be willing to give a written informed consent.;Cohort 3 (3 patients):
- •To enter into this study paediatric patients must meet the following criteria:
- •* Aged * 6 and < 18 years.
- •* Patients who are on topical psoriasis treatment or on stable doses of systemic anti-psoriatic treatment.
- •* Paediatric patients and/or their guardians must be willing to give a written informed consent.
Exclusion Criteria
- •* Patients with stable plaque psoriasis according to a dermatologist.
- •* Patients with a history or signs of other inflammatory skin diseases, for example atopic dermatitis.
- •* Patients on systemic anti-psoriatic treatment.
- •* Patients unwilling or unable to give informed consent.;Cohort 2:
- •Patients will be excluded from this study when any of the following criteria listed below are met:
- •* Patients with a history or signs of other inflammatory skin diseases, for example atopic dermatitis.
- •* Patients on systemic anti-psoriatic treatment.
- •* Patients with a known Koebner phenomenon.
- •* Patients unwilling or unable to give informed consent.;Cohort 3:
- •* aged <6 or *18 years of age.
- •* Patients with a history or signs of other inflammatory skin diseases, for example atopic dermatitis.
- •* Patients using varying doses of systemic anti-psoriatic treatment (like methotrexate or biologics). Doses have to be stable for at least three months.
- •* Patients in which the dose of systemic treatment is likely to change over the next three months.
- •* Patients or parents unwilling or unable to give informed consent.
Investigators
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