An Assessment of Aspirin Plus Prednisone Treatment for Euthyroid Women With Thyroid Autoimmunity Undergoing In Vitro Fertilization
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 402
- 试验地点
- 2
- 主要终点
- clinical pregnancy rate
研究概览
简要总结
Thyroid autoimmunity(TAI) per se have adverse effect on pregnancy outcomes，and aspirin and prednisone were used frequently in antithyroid antibodies(ATA) positive infertile women in clinical practice, but the impact of these medicines is still controversial. Therefore, aim of the study was to investigate whether or not the treatment of prednisone in addition to aspirin was capable of improving reproductive outcomes in euthyroid infertile women.
详细描述
A multicenter retrospective study performed during the period of 2017 to 2020 and euthyroid infertile women positive for anti-thyroperoxidase antibody (TPOAb) and/or thyroglobulin antibody (TgAb) alone with thyroid stimulating hormone 0.35-4.0mIU/L undergoing first in vitro fertilization and embryo transfer(IVF-ET) cycle were recruited in our study.Data analysis was performed using the Statistics Package for Social Sciences.In the end, the value of prednisone plus aspirin treatment was investigated to make a big contribution on clinical practice.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Both TPOAb and TgAb in all the subjects were measured before ART procedure
- •Thyroid stimulating hormone (TSH) level ranged from 0.35-4.0mIU/L
- •Women underwent first embryo transfer without previous IVF history.
排除标准
- •Abnormal thyroid function test
- •Women with known autoimmune diseases or clinical presentations of autoimmune disorders
研究组 & 干预措施
P+A group
aspirin: tablet 100mg qd 2-5weeks prednisone: tablet 10mg qd 2-5weeks
干预措施: Prednisone 10 MG+aspirin 100MG (Drug)
结局指标
主要结局
clinical pregnancy rate
时间窗: 3 mouths
Clinical pregnancy was defined as the existence of a viable embryo within an intrauterine gestational sac
次要结局
未报告次要终点