Improvement Assessment of Coronary Flow Dysfunction Using Fundamental Fluid Dynamics
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Coronary Artery Disease
- Sponsor
- University of Cincinnati
- Enrollment
- 68
- Locations
- 1
- Primary Endpoint
- Quantification of relative contributions of large artery disease and microvascular disease
- Status
- Active, Not Recruiting
- Last Updated
- 11 months ago
Overview
Brief Summary
Diagnosis of relative contributions of large artery blockages and microvascular blockages is very much needed in the treatment of coronary artery disease. In order to achieve this, two novel parameters, pressure drop coefficient (CDP), which combines flow and pressure readings and Lesion flow coefficient (LFC), which combines anatomical details of the lesion with pressure and flow readings, are being investigated.
Detailed Description
Diagnosis of relative contributions of large artery blockages and microvascular blockages is very much needed in the treatment of coronary artery disease. In order to achieve this, two novel parameters, pressure drop coefficient (CDP), which combines flow and pressure readings and Lesion flow coefficient (LFC), which combines anatomical details of the lesion with pressure and flow readings, are being investigated. The diagnostic parameters will be correlated with Coronary Flow Reserve (CFR)values obtained using Positron Emission Tomography (PET) imaging. They will also be correlated with Fractional Flow Reserve (FFR).
Investigators
Rupak K. Banerjee
Professor
University of Cincinnati
Eligibility Criteria
Inclusion Criteria
- •18 years of age or above
- •Patients referred to a stress test by a Cardiologist
- •Acute Chest pain, as per patient input.
- •Risk Assessment with prior test results and/or previous history of known chronic stable CAD.
- •Borderline or discordant stress testing where obstructive CAD remains a concern.
- •New or worsening symptoms- Abnormal coronary angiography or abnormal prior stress imaging study.
- •Coronary stenosis or anatomic abnormality of uncertain significance.
- •In absence of reliable diagnostic information from another imaging modality.
Exclusion Criteria
- •Left ventricular ejection fraction less the 25% determined by gated SPECT imaging
- •Non-dialysis dependent chronic kidney disease with baseline serum creatinine greater than 2.5 gm/dL.
- •History of type II heparin-induced thrombocytopenia.
- •Significant co-morbid condition that is medically unstable and would make coronary angiography prohibitive or contraindicated.
- •Pregnant women.
- •Incapacitated for Consent
Outcomes
Primary Outcomes
Quantification of relative contributions of large artery disease and microvascular disease
Time Frame: 2 years
Correlation Coronary Flow Reserve (CFR) from Positron Emission Tomography (PET)imaging with diagnostic parameters, Pressure Drop Coefficient (CDP) and Lesion Flow Coefficient (LFC).
Secondary Outcomes
- Quantification of relative contributions of large artery disease and microvascular disease(2 years)