Two vs. one high-frequency rTMS session per day for treatment-resistant depressio
Not Applicable
Completed
- Conditions
- DepressionMental and Behavioural Disorders
- Registration Number
- ISRCTN71929667
- Lead Sponsor
- First Psychiatry Dept., Eginition Hospital, National and Kapodistrian University of Athens (Greece)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 98
Inclusion Criteria
1. Meet DSM-IV-TR criteria for current non-psychotic major depressive disorder
2. Have treatment resistant depression (with failure of at least two trials of two different antidepressants)
3. 18-59 years of age
4. Right handed
5. Be naïve to TMS
Exclusion Criteria
1. History of seizures
2. History of head injury with loss of consciousness
3. History of brain surgery
4. History of presence of metallic implants
5. History of dementia or other Axis I diagnosis
6. History of substance dependence or abuse within the previous 6 months
7. Pregnancy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Difference from baseline in Hamilton Depression Rating Scale (HDRS) score and Clinician Global Impressions-Severity of Illness (CGI-S) score at the end of treatment and follow-up.
- Secondary Outcome Measures
Name Time Method