Effects of sitagliptin and vildagliptin on glucose fluctuations in patients with type 2 diabetes -prospective open-label controlled study
Phase 4
- Conditions
- type 2 diabetes mellitus
- Registration Number
- JPRN-UMIN000005627
- Lead Sponsor
- Department of Medicine II, Hokkaido University Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Not provided
Exclusion Criteria
1) patients who received insulin injection therapy 2) severe hepatic dysfunction, renal dysfunction, heart failure 3) history of anaphylaxis of Sitagliptin or Vildagliptin, 4) pregnancy and lactation 5) patients who are inadequate to enter this study due to the other reasons by physician's judgments
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To evaluate changes in MAGE; mean amplitude of glycemic excursions before and after switching from sitagliptin to vildagliptin, and vice versa
- Secondary Outcome Measures
Name Time Method 1) M-value 2) fasting plasma glucose, HbA1c, glycoalbumin 3) beta cell function 4) changes in body weight, Body Mass Index, abdominal girth, blood pressure 5) several biomarkers