Onderzoek microbioom gezonde kinderen.
Recruiting
- Conditions
- Microbiome (microbioom)Healthy infant (gezond kind)Delivery mode (partus)
- Registration Number
- NL-OMON27482
- Lead Sponsor
- Wetenschapsbureau Linneaus instituut Hoofddorp
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
1. Term neonates;
2. Born in the region of Groot Kennemerland and bollenstreek (draining on Spaarne hospital Hoofddorp or Kennemer Gasthuis Haarlem).
Exclusion Criteria
1. Severe perinatal/ neonatal/ maternal complications as asphyxia, resuscitation, transfer to neonatal intensive care unit etc;
2. Major congenital anomalies;
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Comparison of the composition of infant microbiome between infants born vaginally and infants born by caesarean section at several time points during the first 12 months of life;<br /><br>2. The dynamics of the infant nasopharyngeal and oral microbiome in periods of respiratory infections.
- Secondary Outcome Measures
Name Time Method 1. The relation between nasopharyngeal, oral, gastrointestinal and skin microbiome;<br /><br>2. The dynamics of the infant microbiome in periods of antibiotic consumption;<br /><br>3. Comparison of the composition of the maternal microbiome and the infant microbiome;<br /><br>4. Comparison of the composition of the infant microbiome between breastfed infants and formula fed infants;<br /><br>5. The dynamics of the infant microbiome in case of eczema/atopic diseases;<br /><br>6. The dynamics of the infant microbiome related to exposure (siblings, day care).