Effects of Cardiac Rehabilitation on Exercise Tolerance, Endothelial Function, Heart Variability and Quality of Life in Heart Transplants.

Not Applicable

Recruiting

• Conditions: Heart Transplantation; E04.100.376.475

• Registration Number: RBR-32vrj6
• Lead Sponsor: niversidade Federal de Pernambuco-UFPE

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-05-11
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Individuals with an age range greater than 18 years and less than 65 years of age; of both sexes; who underwent heart transplant surgery in a superior period for 6 months; with clinical stability; using regular immunosuppressive therapy, with no change in class of medications within three months prior to the start of the study

Exclusion Criteria

Patients who present with orthopedic, neurological or respiratory diseases that may make it impossible to perform cardiopulmonary and exercise tests; patients who are undergoing dialysis; and those patients who present psychic alterations that restrict them to respond to the questionnaires and the elderly who carry out the test Time up and go in time greater than 20 seconds, characterizing risk of falls

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Expected outcome 1<br>Maximum oxygen consumption (VO2max) as measured by Ergospirometry.;Expected outcome 2<br>Heart rate variability through time domain analysis parameters: mean RR, SDNN, SDNNi, SDANN, rMSSD and PNN50, and frequency domain analysis: AF, BF and BF / AF measured by Holter.<br>;Expected outcome 3<br>Endothelial function through the RHI (Reactive hyperemia index analyzed by EndoPAT 2000.;Expected outcome 4<br>Quality of life measured through the Short Form-36 questionnaire (SF-36).

Secondary Outcome Measures

Name	Time	Method
Expected outcome 1<br>Distance traveled in meters obtained in the Six-Minute Walk Test (TC6)<br>;Expected outcome 2<br>Symptoms of depression through the Beck Depression Inventory (BDI);Expected outcome 3 <br>Inspiratory muscle strength measured by the Digital Manovacuometer (GlobalMed)