Impact of Verticalization on Intracranial Hemodynamics Assessed in Transcranial Doppler at the Acute Phase of Cerebral Infarction (STAND : iSchemic sTroke evAluated at Bed Side With ultrasouND)
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 36
- 试验地点
- 1
- 主要终点
- Percentage of patients with a change in mean cerebral artery velocity (MCAVM) in transcranial Doppler
研究概览
简要总结
The management of patients with ischemic stroke or transient ischemic attack is based on the preservation of a brain area by maintaining sufficient intracranial hemodynamics (IH) and with rapid recanalization.
The impact of the patient's position (supine or seated position) on the IH in the event of narrowing or occlusion of an artery is poorly assessed but may be of particular importance. Variations in blood flow according to the positioning of the patient's body are measurable using a transcranial Doppler.
The main objective is to verify whether intracerebral hemodynamic changes during early verticalization after ischemic stroke or transient ischemic attack are more frequent in patients with carotid stenosis or occlusion compared to those without stenosis or occlusion.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Ischemic stroke (AIC) or transient ischemic attack (AIT) of the carotid artery
- •Duration of symptoms less than 48 hours
- •Absence of homolateral or downstream intracranial stenosis or occlusion M1
- •Lifting authorized by the referent clinician.
- •Rankin's score before AIC/AIT ≤ 2
- •For cases:
- •Carotid stenosis of more than 50% NASCET (North American Symptomatic Carotid Endarterectomy Trial) or an occlusion
- •For controls:
- •Absence of carotid stenosis greater than 50% NASCET (North American Symptomatic Carotid Endarterectomy Trial) or occlusion
排除标准
- •Disrupted vigilance
- •Secondary exclusion criteria:
- •Absence of a homolateral temporal acoustic window at the lesion
- •Impossibility to verticalize the patient
结局指标
主要结局
Percentage of patients with a change in mean cerebral artery velocity (MCAVM) in transcranial Doppler
时间窗: 2 minutes
Percentage of patients with a change in mean cerebral artery velocity (MCAVM) in transcranial Doppler (defined by a variation of more than 10%) on the symptomatic side evaluated in transcranial Doppler when changing from the lying position (0°) to the 90° position (measured 2 minutes after verticalization).
次要结局
未报告次要终点