Examining the Effect of Salbutamol Use in Asthma and/or Exercise Induced Bronchoconstriction Whilst Exercising in Ozone Air Pollution
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 1
- 主要终点
- Measured Before and 30 Minutes After Exercise in Each 1 Day Condition
研究概览
简要总结
Salbutamol use is increased in areas with high levels of ozone pollution and the potential consequences of this are not well known. The purpose of this study is to examine the effect of salbutamol on lung function and inflammation in people with asthma and/or EIB exercising in ozone air pollution. To examine this, we are planning a randomized cross over trial where people with asthma and/or EIB complete sub maximal exercise in four conditions on four separate days. The four condition are: ozone + salbutamol, filtered air + salbutamol, ozone + placebo medication, and filtered air + placebo medication.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
盲法说明
Drug condition (placebo or salbutamol) will be double blinded Air quality condition (ozone or filtered air) will be single blinded
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Have asthma and/or EIB
- •Able to perform maximal exercise
- •Able to communicate sufficiently using the English language
排除标准
- •Allergic to salbutamol (also known as Ventolin)
- •Pregnant or potentially pregnant
- •Have a history of smoking
- •Had an upper respiratory tract infection within the last 4 weeks
- •Have a chronic respiratory disease other than asthma or EIB
研究组 & 干预措施
Exercising in ozone following salbutamol inhalation
Participants will be doing sub-maximal exercise (60% of VO2max for 30 minutes) on a cycle ergometer while inhaling 170ppb ozone after inhaling 200ug of salbutamol.
干预措施: Salbutamol (Drug)
Exercising in ozone following salbutamol inhalation
Participants will be doing sub-maximal exercise (60% of VO2max for 30 minutes) on a cycle ergometer while inhaling 170ppb ozone after inhaling 200ug of salbutamol.
干预措施: Ozone (Other)
Exercising in ozone following salbutamol inhalation
Participants will be doing sub-maximal exercise (60% of VO2max for 30 minutes) on a cycle ergometer while inhaling 170ppb ozone after inhaling 200ug of salbutamol.
干预措施: Exercise (Other)
Exercising in filtered air following salbutamol inhalation
Participants will be doing sub-maximal exercise (60% of VO2max for 30 minutes) on a cycle ergometer while inhaling filtered air after inhaling 200ug of salbutamol.
干预措施: Salbutamol (Drug)
Exercising in filtered air following salbutamol inhalation
Participants will be doing sub-maximal exercise (60% of VO2max for 30 minutes) on a cycle ergometer while inhaling filtered air after inhaling 200ug of salbutamol.
干预措施: Filtered Air (Other)
Exercising in filtered air following salbutamol inhalation
Participants will be doing sub-maximal exercise (60% of VO2max for 30 minutes) on a cycle ergometer while inhaling filtered air after inhaling 200ug of salbutamol.
干预措施: Exercise (Other)
Exercising in ozone following placebo inhalation
Participants will be doing sub-maximal exercise (60% of VO2max for 30 minutes) on a cycle ergometer while inhaling 170ppb ozone after inhaling placebo medication.
干预措施: Placebo medication (Drug)
Exercising in ozone following placebo inhalation
Participants will be doing sub-maximal exercise (60% of VO2max for 30 minutes) on a cycle ergometer while inhaling 170ppb ozone after inhaling placebo medication.
干预措施: Ozone (Other)
Exercising in ozone following placebo inhalation
Participants will be doing sub-maximal exercise (60% of VO2max for 30 minutes) on a cycle ergometer while inhaling 170ppb ozone after inhaling placebo medication.
干预措施: Exercise (Other)
Exercising in filtered air following placebo inhalation
Participants will be doing sub-maximal exercise (60% of VO2max for 30 minutes) on a cycle ergometer while inhaling filtered after inhaling placebo medication.
干预措施: Placebo medication (Drug)
Exercising in filtered air following placebo inhalation
Participants will be doing sub-maximal exercise (60% of VO2max for 30 minutes) on a cycle ergometer while inhaling filtered after inhaling placebo medication.
干预措施: Filtered Air (Other)
Exercising in filtered air following placebo inhalation
Participants will be doing sub-maximal exercise (60% of VO2max for 30 minutes) on a cycle ergometer while inhaling filtered after inhaling placebo medication.
干预措施: Exercise (Other)
结局指标
主要结局
Measured Before and 30 Minutes After Exercise in Each 1 Day Condition
时间窗: Measured before and 30 minutes after exercise in each 1 day condition
Measure of pulmonary function
Change in FVC From Baseline to 30 Minutes After Exercise
时间窗: Measured before and 30 minutes after exercise in each 1 day condition
Measure of pulmonary function
次要结局
未报告次要终点
研究者
Michael Koehle
Professor
University of British Columbia