Effect of Pentoxyphiline on preventing acute kidney injury after cardiac surgery
Phase 2
- Conditions
- Acute Renal Failure.Acute Renal Failure, unsepecified
- Registration Number
- IRCT138807302622N1
- Lead Sponsor
- Tehran Heart Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
Adultpatients who underwent coronary artery bypass graft surgery with a definite indication.
Exclusion criteria:
1- Renal failure; 2- Hepatic gailure; 3-History of gasterointestinal bleeding or Central nervous system hemorrhage; 4- Severe Arrhythmia; 5-Persistant hypotension; 6- Recent corticosteroid therapy; 7-Methylxanthine treatment; 8-Severe coagulopathies; 9-Uncontrolled diabetes mellitus; 10- Sepsis; 11-Active urinary tract infection; 12 Angiography in the past 7 days; 13-Treatment with Diltiazem or Nitroprusside; 14-Collagen vascular disease.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method GAL reduction. Timepoint: 3 and 24 hour following operation. Method of measurement: Blood test.
- Secondary Outcome Measures
Name Time Method Decreasing renal failure. Timepoint: 24 hours after operation. Method of measurement: Serum creatinine level every 24 hours post operation.