Structural and Microbiological Characterization of Arterial Catheter Biofilm in ICU's Patients Using Optical Coherence Tomography
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Enrollment
- 60
- Locations
- 2
- Primary Endpoint
- Biofilm structure type (ribbon-shaped or mushroom-shaped), measured with D-FF-OCT
Study Overview
Brief Summary
29.3% of bacteremias in intensive care units (ICU) are linked to vascular devices, including 7.7% to arterial catheters, with an influence on both morbility and mortality.
It is now accepted that biofilm as a role on bacterial development on inner surface of vascular devices but there is yet a lack of clinical relevant data documenting a causal relation between biofilm formation and bacteremias.
The investigators assume that a better structural and microbiological characterization of arterial catheter biofilm in ICU patients could help preventing bacteremias or have a more specific treatment when it appears.
Study Design
- Study Type
- Observational
- Observational Model
- Other
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patient or relative informed of the study and having declared their non-objection
- •Patient over 18 years old
- •Patient hospitalized in ICU with an arterial catheter
Exclusion Criteria
- •Patient unable to express consent
- •Patient whose collection of the arterial catheter is impossible or for whom storage at 4°C is impossible
- •Patient with arterial catheter removed outside the usual procedure of the ICU
- •Patient admitted in ICU with an arterial catheter already in place
Arms & Interventions
OCT-BIO-KTA cohort
Critically ill patient > 18 years of age with artherial catheter for >2 calendar days in ICU
Intervention: OCT-BIO-KTA cohort (Other)
Outcomes
Primary Outcomes
Biofilm structure type (ribbon-shaped or mushroom-shaped), measured with D-FF-OCT
Time Frame: Outcome measure is assessed 2 days following catheter removal
Provide a better understanding of the relation between structural and microbiological characterization of artherial catheter biofilm in ICU patients using D-FF-OCT
Secondary Outcomes
- Bacterial or fungal indentification(Outcome measure is assessed 2 days following catheter removal)
- Biofilm thickness, measured with D-FF-OCT(Outcome measure is assessed 2 days following catheter removal)
- Biofilm dynamic signal distribution, measured with D-FF-OCT(Outcome measure is assessed 2 days following catheter removal)