The Effect of Oxycodone to the Placental Circulation at Early Labour
- Registration Number
- NCT02573831
- Lead Sponsor
- Kuopio University Hospital
- Brief Summary
Oxycodone is used to treat pain in early labor, however the effect of oxycodone to placental or fetal circulation has not been evaluated. Oxycodone is increasingly used to treat labor pain in the early phase. The aim of the randomised, double blinded, placebo controlled study was to evaluate the effects of oxycodone in placental circulation, efficacy and safety of oxycodone and the effects to the newborn.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- Female
- Target Recruitment
- 22
Inclusion Criteria
-
oxycodone planned for pain relief
- age 18 years or more
- Informed consent obtained
- Full term pregnancy
Exclusion Criteria
-
No oxycodone planned
- age less than 18 years
- No informed consent
- not full term pregnancy
-
Other contraindication to oxycodone
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Placebo The patients are given at first placebo and after one hour oxycodone 0,05 mg/kg if needed Oxycodone Oxycodone The patients are given at first oxycodone 0,05 mg/kg and after one hour oxycodone 0,05 mg/kg if their pain in numerical rating scale from 0 to 10 is 5 or more
- Primary Outcome Measures
Name Time Method placental blood flow from zero hours to two hours after the first study drug Placental blood flow is measured with doppler ultrasound
- Secondary Outcome Measures
Name Time Method uterine arterial flow from zero hours to two hours after the first study drug uterine arterial flow is measured with doppler ultrasound
Trial Locations
- Locations (1)
Kuopio University Hospital
🇫🇮Kuopio, Northern Savo, Finland