Relieving the Bile Ducts Prior to Pancreatoduodenectomy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 722
- 试验地点
- 1
- 主要终点
- 30-day Mortality
研究概览
简要总结
The aim of this study was to assess the risk and complications after preoperative drainage of biliary obstruction in patients who underwent pancreatoduodenectomy.
A retrospective cohort study of all patients who underwent pancreatoduodenectomy from January 1st, 2015 to September 30th, 2021. Patients who had preoperative bile duct drainage were compared to patients without intervention. Type of interventions, complications and outcome after surgery were compared using univariate and multivariate analysis.
详细描述
Obstructive jaundice is a common problem in pancreatic and periampullary tumors, but preoperative biliary drainage in patients with hyperbilirubinemia is still controversial. The aim of this retrospective cohort study was to assess the risk and complications after preoperative drainage of biliary obstruction in patients who underwent pancreatoduodenectomy.
A retrospective cohort study of all patients who underwent pancreatoduodenectomy from January 1st, 2015 to September 30th, 2021.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients who had undergone pancreatoduodenectomy
排除标准
- 未提供
结局指标
主要结局
30-day Mortality
时间窗: up to 30 days
30-day mortality rate post-pancreatoduodenectomy
90-day Mortality
时间窗: up to 90 days
90-day mortality rate post-pancreatoduodenectomy
Length of Hospital Stay
时间窗: Days from admission until discharge, up to 390 days, median time 13 days
Accumulated length of hospital stay from the admission day prior to pancreatoduodenectomy, till the day of discharge.
30-day Readmission
时间窗: up to 30-days from hospital discharge
Prevalence of readmission within 30-days after discharge following pancreatoduodenectomy.
Post-operative complication score (Clavien-Dindo)
时间窗: During hospital admission, median time 13 days, up to 390 days.
The prevalence of complications graded according to Clavien-Dindo score after pancreatoduodenectomy. Clavien-Dindo 0 is no complications, Clavien-Dindo 5 means complications resulting in mortality.
次要结局
- Histological Specimen(Obtained within 21 days after resection)
- Complications following preoperative bile duct drainage(up to 7 days after bile duct drainage)
- Time from Bile Duct Drainage to Pancreatoduodenectomy(Days from bile duct decompression to pancreatoduodenectomy, median time 32 days, up to 534 days)
研究者
Waqas Farooqui
Principal Investigator
Rigshospitalet, Denmark