An investigation into why people with kidney disease lose muscle and feel weak

Not Applicable

Completed

• Conditions: Chronic kidney disease; Urological and Genital Diseases

• Registration Number: ISRCTN18221837
• Lead Sponsor: niversity Hospitals of Leicester (UK)

Brief Summary

2022 Results article in https://pubmed.ncbi.nlm.nih.gov/35090033/ (added 18/09/2023) 2019 Results article in https://pubmed.ncbi.nlm.nih.gov/31914685/ (added 18/09/2023) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/35029054/ (added 18/09/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-02-10
• Study Completion: 2020-11-02
• Last Update Posted: 3 October 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 73

Inclusion Criteria

CKD patients:
1. Over 18 years of age
2. Diagnosed CKD stage 3b-5
3. If diabetic, good control - HbA1c <9%

Matched controls - will be matched to CKD patients for age, sex and race.
1. Over 18 years of age
2. Kidney function < 80mL/min/1.73m2
3. Good general health

Exclusion Criteria

CKD patients:
1. Aged under 18 years
2. Uncontrolled diabetes mellitus (HbA1c >9%)
3. Inability to give consent for any reason

Matched controls:
1. Aged under 18 years
2. Presence of CKD (eGFR>80mL/min/1.73m2)
3. Presence of other diseases known to cause muscle wasting (some cancers, sepsis, burns and HIV)
4. Inability to give informed consent for any reason.

Study & Design

• Study Type: Observational
• Study Design: Not specified