eurological sequelae and changes in nociception after severe sepsis or septic shock - NeuroPain

Integriertes Forschungs- und Behandlungszentrum (IFB) Sepsis und Sepsisfolgen: Center for Sepsis Control and Care (CSCC); Universitätsklinikum Jena0 sites120 target enrollmentMarch 21, 2011

ConditionsA41 R57.2 K72.7 Other sepsis Septic shock

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: A41
Sponsor: Integriertes Forschungs- und Behandlungszentrum (IFB) Sepsis und Sepsisfolgen: Center for Sepsis Control and Care (CSCC); Universitätsklinikum Jena
Enrollment: 120
Status: Recruiting
Last Updated: last year

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

No summary available.

Registry

who.int

Start Date

March 21, 2011

End Date

TBD

Last Updated

last year

Study Type

Observational

Sex

All

Investigators

Sponsor

Integriertes Forschungs- und Behandlungszentrum (IFB) Sepsis und Sepsisfolgen: Center for Sepsis Control and Care (CSCC); Universitätsklinikum Jena

Eligibility Criteria

Inclusion Criteria

•Common inclusion criteria (all participants):
•Minimum age: 18; informed consent, sufficient skills in German language;
•Sepsis specific: Maximum age: 85, survivors of severe sepsis/ septic shock; duration of mechanical ventilation \= 3 days in ICU;
•non septic ICU patients: Maximum age: 85;duration of mechanical ventilation \= 3 days in ICU;
•HE sepcific: Maximum age: 65; confirmed diagnosis of liver failure (sonographic, CT, histological); HE\-grade 0\-2,
•Control specific: Maximum Age for neurological examinations: 65 and 85 years for pain examinations

Exclusion Criteria

•common exclusion criteria (for all participants):
•Participation in a different study; confirmed diagnosis of dementia or other severe neurological disorder (epilepsy included); seizure, confirmed septic shock or severe sepsis in anamnesis; recent drug abuse and/ or alcohol intoxication
•sepsis specific: medication with analgetics; Amputation of upper limbs; confirmed chronic or other neuropathic pain disorder;
•additionally for neurological examinations (25 patients): Medication with neuroleptics, sedatives, antidepressants, Amaurosis
•non\-septic ICU patients: ICU stay due to sepsis or septic shock; medication with analgetics; Amputation of upper limbs; confirmed chronic or other neuropathic pain disorder;
•HE\-specific: Medication with neuroleptics, sedatives, antidepressants, Amaurosis; life expectancy \< 1 year; spontaneous bacterial peritonitis; actual delir and/ or deprivation; liver transplantation
•control specific: medication with analgetics, amputation of the upper limbs; confirmed confirmed chronic or other neuropathic pain disorder; medication with neuroleptics, sedatives, antidepressants, Amaurosis;
•MEG and MRI\-sepcific: pace maker and other magnetic implants; claustrophobics; pregnancy