How do we predict if a pressurized breathing mask might fail in supporting our patients?

Not Applicable

Completed

• Conditions: Prediction of non-invasive failure in pneumonia patients with acute lung injury; Influenza and pneumonia; Respiratory

• Registration Number: ISRCTN14641518
• Lead Sponsor: Cairo University Hospitals

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2020-06-30
• Study Start: 2020-09-17
• Last Update Posted: 28 September 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 177

Inclusion Criteria

1. All patients admitted to the ICU for NIV due to pneumonia with hypoxemic respiratory failure and mild to moderate ARDS i.e. P/F ratio <300
2. Diagnosis of pneumonia established upon clinical findings and radiologic findings, compatible with pneumonia diagnosis

Exclusion Criteria

1. Presence of do-not-intubate orders
2. Presence of chronic obstructive pulmonary disease
3. Requirement for emergency intubation
4. Severe ARDS i.e. P/F ratio < 150
5. NIV intolerance

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
IV failure, defined as the transition of the patient to invasive ventilation due to worsening clinical condition (drop in blood pressure or drop in conscious level), worse blood gases (increase in carbon dioxide or drop in oxygen), or patient refusal to continue on non-invasive ventilation. Timepoints: within the first 48 hours of non-invasive intervention.

Secondary Outcome Measures

Name	Time	Method
Prediction of non-invasive failure using the HACOR score calculated at 0, 1, 12, 24 hours