Metabolic Syndrome and Female Breast Cancer: a Case-control Study in Southern Brazil
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 164
- 主要终点
- Odds Ratio for Breast Cancer according to the presence of Metabolic Syndrome and its components
研究概览
简要总结
The role among metabolic syndrome and breast cancer risk is not well understood and must be further explored. The objective of this study is to evaluate the association between metabolic syndrome and breast cancer in Southern Brazil. In this case-control study, breast cancer patients and controls without malignant disease, matched for age (±5 years) and menopausal status, were interviewed and asked to make a glucose, HDL-cholesterol and triglycerides test. Waist circumference and blood pressure were measured using standardized procedures. Metabolic Syndrome was considered by NCEP ATP III (2001) and IDF (2006) definitions. Cases and controls were compared in relation to the presence of diagnosed MetS (yes/no), number of metabolic abnormalities identified (1 to 5) for each definition, and according to each metabolic abnormality cutoff point.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •For cases: having newly diagnosed breast cancer without adjuvant or neoadjuvant treatment;
- •For controls: having no evidence of cancer; be matched for age and menopausal status with controls
排除标准
- •Women with a recidivated tumor, HIV infection, renal, heart or liver disease, hypothyroidism or hyperthyroidism, mobility or neurological limitations, chronicle use of corticosteroids, pacemakers or identified with severe edema were excluded.
结局指标
主要结局
Odds Ratio for Breast Cancer according to the presence of Metabolic Syndrome and its components
时间窗: Participants will be evaluated only once before the first appointment with the oncologist (cases with a biopsy) and gynecologist (controls). The blood test results for Metabolic Syndrome parameters were collected in an expected average of 30 days.
次要结局
未报告次要终点
研究者
Rafaela Bulow Bergmann
Master in Health and Behavior
Catholic University of Pelotas