ISRCTN55593137
Completed
未知
A randomised trial of radiotherapy alone versus three cycles of cyclophosphamide, doxorubicin, vincristine and prednisolone (CHOP) chemotherapy plus radiotherapy versus six cycles of CHOP chemotherapy plus radiotherapy for early stage aggressive non-Hodgkin's lymphoma
Cancer Research UK (CRUK) (UK)0 sites0 target enrollmentJuly 1, 2001
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- on-Hodgkin's lymphoma
- Sponsor
- Cancer Research UK (CRUK) (UK)
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Biopsy\-proven non\-Hodgkin's lymphoma of any of the following histologies: International Working Formulation groups F, G and H; Kiel Classification: centroblastic B\-cell, pleomorphic medium and large T\-cell, immunoblastic, large cell anaplastic and high grade unclassified; Revised European\-American Classification of Lymphoid Neoplasms (REAL Classification): Diffuse large B\-cell, anaplastic large cell, high\-grade B\-cell or Mucosa\-associated lymphoid tissue (MALT) type, and peripheral T\-cell
- •2\. WHO performance status 0, 1, 2
- •3\. Aged greater than 15 years
- •4\. No previous chemotherapy or radiotherapy 5\. Normal lactic dehydrogenase (LDH)
- •6\. Stage I, IE, II, IIE, except bulky abdominal presentation
- •7\. No B symptoms
- •8\. No previous malignancy, except basal cell carcinoma of the skin or cervical carcinoma stage I
- •9\. No evidence of Human Immunodeficiency Virus (HIV) positively
- •10\. No contraindications to protocol treatments
Exclusion Criteria
- •Patients with testicular, brain, gastrointestinal or skin primaries are excluded
Outcomes
Primary Outcomes
Not specified
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