A randomised trial of radiotherapy alone versus three cycles of cyclophosphamide, doxorubicin, vincristine and prednisolone (CHOP) chemotherapy plus radiotherapy versus six cycles of CHOP chemotherapy plus radiotherapy for early stage aggressive non-Hodgkin's lymphoma
- Conditions
- on-Hodgkin's lymphomaCancerNon-Hodgkin's lymphoma
- Registration Number
- ISRCTN55593137
- Lead Sponsor
- Cancer Research UK (CRUK) (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 0
1. Biopsy-proven non-Hodgkin's lymphoma of any of the following histologies: International Working Formulation groups F, G and H; Kiel Classification: centroblastic B-cell, pleomorphic medium and large T-cell, immunoblastic, large cell anaplastic and high grade unclassified; Revised European-American Classification of Lymphoid Neoplasms (REAL Classification): Diffuse large B-cell, anaplastic large cell, high-grade B-cell or Mucosa-associated lymphoid tissue (MALT) type, and peripheral T-cell
2. WHO performance status 0, 1, 2
3. Aged greater than 15 years
4. No previous chemotherapy or radiotherapy 5. Normal lactic dehydrogenase (LDH)
6. Stage I, IE, II, IIE, except bulky abdominal presentation
7. No B symptoms
8. No previous malignancy, except basal cell carcinoma of the skin or cervical carcinoma stage I
9. No evidence of Human Immunodeficiency Virus (HIV) positively
10. No contraindications to protocol treatments
Patients with testicular, brain, gastrointestinal or skin primaries are excluded
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ot provided at time of registration
- Secondary Outcome Measures
Name Time Method ot provided at time of registration