Isoflurane at Subanesthetic Concentrations - 6

Phase 2

Completed

• Conditions: Opioid-Related Disorders; Substance-Related Disorders
• Interventions: Drug: 40% Nitrous oxide; Drug: 0.6% isoflurane; Other: Sham comparator; Drug: 0.4% isoflurane; Drug: 0.2% isoflurane

• Registration Number: NCT00000254
• Lead Sponsor: University of Chicago

Brief Summary

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To test the hypothesis that isoflurane at subanesthetic concentrations does not reduce cold-water immersion pain in healthy volunteers.

Detailed Description

Not available

Study Timeline

• Study Start: 1995-01
• Primary Completion: 1995-09
• Study Completion: 1995-09
• Study First Submitted: 1999-09-20
• Study First Submitted QC: 1999-09-20
• Study First Posted: 1999-09-21
• Status Verified: 2015-05
• Last Update Submitted: 2015-05-26
• Last Update Posted: 2015-05-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 10

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
0.6% isoflurane	0.6% isoflurane	-
0% isoflurane	Sham comparator	-
0.2% isoflurane	40% Nitrous oxide	-
0.6% isoflurane	40% Nitrous oxide	-
0.4% isoflurane	40% Nitrous oxide	-
0.4% isoflurane	0.4% isoflurane	-
0% isoflurane	40% Nitrous oxide	-
0.2% isoflurane	0.2% isoflurane	-

Primary Outcome Measures

Name	Time	Method
Pain response	Post inhalation	Effects of inhaled isoflurane on pain from immersion of subject's arm in ice cold water. Nitrous oxide (40%) was used as a positive control to confirm sensitivity of the pain assay.

Trial Locations

Locations (1)

University of Chicago, Anesthesia & Critical Care; 🇺🇸 Chicago, Illinois, United States