Developing a reproducible procedure for optimal utilization of platelet-rich plasma and platelet-rich fibrin in aesthetic treatments
- Conditions
- Improving aging skin density and thickness by injecting different types of autologous plasma preparations.Not Applicable
- Registration Number
- ISRCTN10538865
- Lead Sponsor
- Innmedis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 20
1. Female volunteers
2. Aged between 30-60 years old
3. Seeking facial skin rejuvenation
4. Fitzpatrick skin types I to III and facial wrinkles classified as Glogau class II or higher
1. Pregnancy or breastfeeding
2. Blood or platelet disorders
3. Facial surgery in the past year
4. Semi-permanent dermal fillers in the past year
5. Genetic conditions affecting fibroblasts or collagen
6. History of herpes simplex infection
7. Active skin diseases or infections in the treatment area
8. A tendency to develop hypertrophic scars or keloids
9. Immunosuppressive disorders or treatments
10. A history of skin cancer
11. Topical or oral tretinoin use
12. Undergone botulinum toxin and/or dermal filler injections, chemical peelings or laser treatments for facial rejuvenation in the past six months, or planned such treatments in the next six months
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The density of the skin measured using ultrasound before starting the study and then one month after each treatment<br>
- Secondary Outcome Measures
Name Time Method 1. The thickness of the skin measured using ultrasonographic images before starting the study and then one month after each treatment<br>2. The aesthetic improvement of the treated area self-measured by the subjects using the Global Aesthetic Improvement Scale (GAIS) one month after the third treatment <br>3. The level of personal satisfaction with the treatment measured using a questionnaire after completing the treatment