A Split-face, Evaluator-blinded, Randomized Controlled Trial Study Comparing Efficacy between Low-fluence Alexandrite 755-nm Picosecond Laser and low-fluence Neodymium-doped yttrium Aluminum Garnet (Nd:YAG) 1064-nm Picosecond for the Treatment Of Mixed Type Melasma in Asians

Phase 3

Completed

• Conditions: Heathy person; Chloasma, Facial hyperpigmentation, Pigmentary disorder, Postinflammatory hyperpigmentation

• Registration Number: TCTR20220405004
• Lead Sponsor: Division of Dermatology, Department of medicine, Faculty of Medicine, Ramathibodi hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2021-11-30
• Study Start: 2022-04-05
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

Healthy subjects older than 18-year-old

Exclusion Criteria

The exclusion criteria were as follows: (i) severe medical conditions, (ii) other skin diseases on the face, (iii) immunocompromised status, (iv) history of skin cancer or keloids, (v) history of recurrent herpes infection, (vi) coagulopathy, (vii) history of laser/light therapy or other facial procedures at cheek within 2 months prior to the study, (viii) history of chemical peeling for melasma within 2 months prior to the study, (ix) history of topical treatment for melasma within 1 month prior to the study, and/or (x) pregnant or lactation

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Relative lightness index 4 and 8 weeks after completing the 5th treatment sessions colorimeter

Secondary Outcome Measures

Name	Time	Method
Melasma Area and Severity Index (MASI) 4 and 8 weeks after completing the 5th treatment sessions physician (blinded)