'The Effect of Computed Tomography on Rates of Invasive Coronary Angiography in Acute Coronary Syndrome (CRITICAL-ACS)

Not Applicable

Recruiting

Conditions: Acute Coronary Syndrome
Cardiovascular - Coronary heart disease

Registration Number: ACTRN12621000224820

Lead Sponsor: niversity of Otago

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 700

Inclusion Criteria

1)Admission with presumed diagnosis of ACS with either or both of:
•ECG changes indicating new ischaemia,
•Rise and/or fall in troponin
2)Invasive coronary angiography planned
3)New Zealand resident
4)Age greater than or equal to 18 years
5)Provision of written informed consent.

Exclusion Criteria

1)Clinician-determined requirement for urgent (<24 hours) coronary angiography due to clinical instability
2)Prior coronary revascularisation
3)Ineligibility for CTCA or ICA according to local hospital practice
4)Severe chronic kidney disease (eGFR <30 mL/min/1.73m2)
5)Prior recruitment to trial
6)Known pregnancy or currently breast feeding

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Requirement for inpatient invasive coronary angiography (ICA). as assessed from patient medical records.[ During index hospital admission]

Secondary Outcome Measures

Name	Time	Method
Requirement for inter-hospital transfer as assessed from patient medical records.[ During index hospital admission];Time from randomisation to definitive coronary imaging (CTCA or ICA) as assessed from patient medical records.[ Either time of CTCA (if only required test) or time of ICA (in control arm or if ICA required in intervention arm)];The length of time spent in hospital from randomisation to discharge as assessed from patient medical records.[ upon patient discharge];Inpatient coronary revascularization (Coronary Artery Bypass Graft or Percutaneous Coronary Intervention as assessed from patient medical records.[ During index hospital admission];Death or rehospitalisation for any cause as assessed by patient medical record review[ within 30 days after randomisation];Death, or rehospitalisation for any cause as assessed by patient medical record review[ within 360 days after randomisation]