Predictive Value of suPAR and hsCRP on Postoperative Mortality in 951 Patients Undergoing Elective On-pump Cardiac Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 951
- 试验地点
- 1
- 主要终点
- Association of preoperative suPAR values in relation to the censored time-to-event outcome "death from any cause"
研究概览
简要总结
This study aims to investigate whether preoperative soluble urokinase plasminogen activating receptor (suPAR) and High-sensitivity C-Reactive Protein (hsCRP) are independent markers of death after cardiac surgery. Further, to assess whether suPAR and hsCRP provides increased predictive accuracy of the clinical risk model EuroSCORE II. The purpose of the study is to gain knowledge on whether these inflammatory biomarkers might be able to reveal a pro-inflammatory disease state that represents a significant risk in patients undergoing cardiovascular surgery. Hence, these biomarkers may assist clinicians in selecting compassionate treatment for high risk patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Planned elective on-pump cardiac surgery (isolated coronary artery bypass graft (CABG), single and multiple valvular procedures, combined CABG and valvular surgery, and others)
- •Given informed consent on delivering a blood sample for the biobank.
排除标准
- •Peroperatively cancelling the surgery
- •Sudden change to off-pump coronary artery bypass (OPCAB) surgery
- •Death prior to surgery
- •Project blood samples not available.
结局指标
主要结局
Association of preoperative suPAR values in relation to the censored time-to-event outcome "death from any cause"
时间窗: from index surgery to censoring date 12.31.2018
次要结局
- Association of preoperative hsCRP values in relation to the censored time-to-event outcome "death from any cause"(from index surgery to censoring date 12.31.2018)
- Assess whether adding suPAR, hsCRP or combined suPAR+hsCRP measurements improves predictive accuracy of EuroSCORE II(from index surgery to 30 days postoperative)
- Sensitivity of the models; EuroSCORE II, suPAR, hsCRP, suPAR+hsCRP, EuroSCOREII+suPAR, EuroSCOREII+hsCRP and EuroSCOREII+suPAR+hsCRP in relation to the time-to-event outcome "death from any cause"(from index surgery to 30 days postoperative)
- Specificity of the models; EuroSCORE II, suPAR, hsCRP, suPAR+hsCRP, EuroSCOREII+suPAR, EuroSCOREII+hsCRP and EuroSCOREII+suPAR+hsCRP in relation to the time-to-event outcome "death from any cause"(from index surgery to 30 days postoperative)
研究者
Sebastian Roed Rasmussen
Principal Investigator
Rigshospitalet, Denmark