Effect of Periodontal Treatment on Salivary Biomarkers

Not Applicable

• Conditions: Chronic Periodontitis

• Registration Number: NCT02159781
• Lead Sponsor: The Baruch Padeh Medical Center, Poriya

Brief Summary

The investigators plan to recruit 40 healthy patients referred to the unit of Periodontology, diagnosed with generalized moderate - severe chronic periodontitis.

treatment will include 4 - 6 sessions of scaling + root planning, oral hygiene instructions and motivation.

Whole saliva will be collected at intake and 8 - 14 weeks post periodontal treatment.

Saliva will be analyzed for trans locator protein. Study hypothesis: Periodontal treatment has an affect on saliva components.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2014-05-28
• Status Verified: 2014-06
• Study First Submitted QC: 2014-06-09
• Last Update Submitted: 2014-06-09
• Study First Posted: 2014-06-10
• Last Update Posted: 2014-06-10
• Study Start: 2014-07
• Primary Completion: 2015-09
• Study Completion: 2016-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• healthy patients
• moderate - sever chronic periodontitis

Exclusion Criteria

• systemic disease
• pregnancy
• subjects under the age of 18

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Whole saliva & translocator protein (TSPO)	Intake of patients than 8 - 12 weeks after periodontal treatment (scaling & root planning)	Change in whole saliva \& translocator protein (TSPO) post periodontal treatment

Secondary Outcome Measures

Name	Time	Method
Periodontal measurements (periodontal pocket depth, bleeding on probing & clinical attachment level)	Intake 8 - 12 weeks post periodontal treatment (scaling & root planning)	periodontal probing depth, bleeding on probing and clinical attachment level.