ongitudinal characterization of the sensory phenotype of lipohyperplasia dolorosa (LiDo) patients during weight loss and subsequent liposuction.

Recruiting

Conditions: E88.22
ipohyperplasia dolorosa, Lipedema
E88.20
E88.28
E88.21

Registration Number: DRKS00031411

Lead Sponsor: niversität zu Köln

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Female

Target Recruitment: 150

Inclusion Criteria

Generally: female, age between 18-40 years, present signed and irrevoked informed consent.
For LiDo patients for weight reduction: medical diagnosis Lipohyperplasia dolorosa (LiDo), coincident obesity BMI > 40,
For the weight loss group: study-independent planned weight loss to achieve BMI <40 required for lymphatic liposculpture.
For LiDo patients for lymphologic liposculpture: physician diagnosis of lipohyperplasia dolorosa (LiDo),
For the surgery group: lymphological liposculpture planned for study-independent reasons, no coincident obesity; BMI <40.
For obese patients: No medical diagnosis of lipohyperplasia dolorosa (LiDo), obesity BMI > 40.

Exclusion Criteria

Limitation of the ability to communicate (language barrier, cognitive barriers, ...).
Diseases affecting the sensory nervous system (e.g. Parkinson's disease, multiple sclerosis, radiculopathy, injuries of nerves innervating the sensory area of different genesis, diabetic polyneuropathy, peripheral polyneuropathies of different genesis, etc.).
skin stresses on the areas of measurement
topical application of analgesics to the areas of measurement (e.g. plasters, creams, ...)
diagnosed coagulation or wound healing disorder
other known alteration in pain perception or another diagnosed pain disorder
Liposuction already performed prior to study inclusion
Pregnancy

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Characterization of the changes of the different sensory modalities in the clinical phenotype in female patients:<br>QST profiles of all LiDo patients before and after substantial weight reduction.<br>QST profiles of all LiDo patients before and after lymphological liposculpture.<br>QST profiles of obese patients (independent of weight reduction or liposculpture).

Secondary Outcome Measures

Name	Time	Method
The correlation of the primary outcome measures with the pain measures recorded in the pain questionnaire:<br>German pain questionnaire of all patients<br>Pain history questionnaire of all LiDo patients before and after weight reduction or liposuction