Efficacity, Safety and Cost of Intravenous Morphine Titration Alone or Combined to Ketamine

Not Applicable

Completed

• Conditions: Postoperative Pain
• Interventions: Drug: Ketamine

• Registration Number: NCT01146145
• Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Brief Summary

This is a randomised, controlled, double blinded study comparing in the postoperative setting the analgesic efficacy, the safety and the cost in two groups of patients receiving in the postanesthesia care unit either intravenous morphine titration alone or intravenous morphine titration combined to ketamine.

Detailed Description

Randomised, controlled, double blinded study comparing in the postoperative setting the analgesic efficacy, the safety and the cost in two groups of patients receiving in the postanesthesia care unit either intravenous morphine titration alone or intravenous morphine titration combined to ketamine

Study Timeline

• Study Start: 2003-05
• Primary Completion: 2009-01
• Study Completion: 2009-01
• Status Verified: 2010-06
• Study First Submitted: 2010-06-16
• Study First Submitted QC: 2010-06-16
• Last Update Submitted: 2010-06-16
• Study First Posted: 2010-06-17
• Last Update Posted: 2010-06-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 160

Inclusion Criteria

• Age > 18 yrs
• scheduled surgery
• General anesthesia
• ASA I to III
• Able to use a VAS
• No psychological disorders, able to speak french

Exclusion Criteria

• Age < 18 yrs
• Locoregional anesthesia or analgesia
• Allergia to morphine or ketamine
• Morphine or ketamine contraindication
• Pregnancy or breast-feeding

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
treatment	Ketamine	intravenous morphine titration combined to ketamine
placebo	Ketamine	morphine titration alone

Primary Outcome Measures

Name	Time	Method
analgesic efficacy	24 h	the analgesic efficacy, in two groups of patients recevieving in the postanesthesia care unit either intravenous morphine titration alone or intravenous morphine titration combined to ketamine

Trial Locations

Locations (1)

Hopital Louis Mourier; 🇫🇷 Colombes, France