Efficacity, Safety and Cost of Intravenous Morphine Titration Alone or Combined to Ketamine
Overview
- Phase
- N/A
- Intervention
- Ketamine
- Conditions
- Postoperative Pain
- Sponsor
- Assistance Publique - Hôpitaux de Paris
- Enrollment
- 160
- Locations
- 1
- Primary Endpoint
- analgesic efficacy
- Status
- Completed
- Last Updated
- 15 years ago
Overview
Brief Summary
This is a randomised, controlled, double blinded study comparing in the postoperative setting the analgesic efficacy, the safety and the cost in two groups of patients receiving in the postanesthesia care unit either intravenous morphine titration alone or intravenous morphine titration combined to ketamine.
Detailed Description
Randomised, controlled, double blinded study comparing in the postoperative setting the analgesic efficacy, the safety and the cost in two groups of patients receiving in the postanesthesia care unit either intravenous morphine titration alone or intravenous morphine titration combined to ketamine
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age \> 18 yrs
- •scheduled surgery
- •General anesthesia
- •ASA I to III
- •Able to use a VAS
- •No psychological disorders, able to speak french
Exclusion Criteria
- •Age \< 18 yrs
- •Locoregional anesthesia or analgesia
- •Allergia to morphine or ketamine
- •Morphine or ketamine contraindication
- •Pregnancy or breast-feeding
Arms & Interventions
treatment
intravenous morphine titration combined to ketamine
Intervention: Ketamine
placebo
morphine titration alone
Intervention: Ketamine
Outcomes
Primary Outcomes
analgesic efficacy
Time Frame: 24 h
the analgesic efficacy, in two groups of patients recevieving in the postanesthesia care unit either intravenous morphine titration alone or intravenous morphine titration combined to ketamine