EUCTR2008-006371-67-GB进行中（未招募）1 期
EFFECT OF THIENOPYRIDINE DERIVATIVE (CLOPIDOGREL) ON THE DISPOSITION OF EFAVIRENZ AND NEVIRAPINE IN HIV POSITIVE PATIENTS - Interaction between HIV drugs (NNRTIs) and Anti-platelet agent
Royal Liverpool and Broadgreen University Hospital0 个研究点目标入组 37 人开始时间: 2010年9月6日最近更新:
适应症
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 37
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- All
入选标准
- •Inclusion Criteria
- •HIV positive
- •Age 18 years and above
- •On EFV or NVP containing regimen for greater or equal to 6 months
- •Viral load less than or equal to 40 copies/ml and any CD4 count
- •No Laboratory evidence of NNRTI toxicity : ALT =ULN; Bilirubin =ULN;Albumin =30g;Creatinine =ULN
- •Not pregnant (for contraception, patients would be advised to use non-estrogen based contraceptive devices)
- •No inter-current acute illness.
- •No past medical history of coronary heart disease.
- •No history of bleeding diathesis
- •No history of allergy to thienopyridines
- •Exclusion Criteria
- •Unable to provide informed consent
- •Known or suspected poor adherence to ART
- •Continuing IV drug user
- •On HIV protease inhibitor or any known P450 inhibitors or inducers
- •Neutrophils= 3.0 x 109/ml; HB 11.0g/dl
- •Platelets = 100 x 109/l
- •Are the trial subjects under 18?
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range
- •F.1.3 Elderly (>=65 years)
- •F.1.3.1 Number of subjects for this age range
排除标准
- •.Unable to provide informed consent
- •.Known or suspected poor adherence to ART
- •.Continuing IV drug user
- •.On a PI or any other known P450 inhibitors or inducers
- •.Platelets <100x109 L-1
- •.Neutrophils = 1.0 x 109/ml
研究者
相似试验
已完成
不适用
Interaction between human immunodeficiency virus (HIV) drugs (non-nucleoside reverse transcriptase inhibitors [NNRTIs]) and anti-platelet agentsISRCTN68035289Royal Liverpool University Hospital and the University of Liverpool?s Biomedical Research Centre (UK)37
已完成
3 期
Pharmacodynamic comparison of thienopyridine loading strategies in patients undergoing elective coronary stentingI25Chronic ischaemic heart diseaseDRKS00006102niversitäts-Herzzentrum Freiburg - Bad Krozingen300
已完成
不适用
The effect of changing thienopyridine drugs on platelet aggregation for patients with acute and elective stent placement in coronary arteryIschemic heart diseases with PCIJPRN-UMIN000015122Kurume University Hospital150
进行中（未招募）
不适用
Impact of Clopidogrel on diameter and wall thickness of coronary arteries after heart transplantatioTransplant vasculopathy after heart transplantation characterized by Stanford type B2 lesions in coronary angiography and by microvasculopathy proven in biopsy.EUCTR2009-016914-25-DEDeutsches Herzzentrum Berlin
进行中（未招募）
不适用
ETAMI-Study is a clinical trial that tests whether treatment with a new drug (thienopyridine) is able to improve performance and outcome of PCI (i.e. balloon inflation to re-open an occluded vessel in the heart) in patients that suffered myocardial infarction (i.e. acute disease in which one ore more of the blood vessels supplying the heart itself are occluded).EUCTR2010-019461-29-DEStiftung Institut für Herzinfarktforschung70