Nutrition-Related Biomarkers in Predicting Breast Cancer Risk in Women
- Conditions
- Breast Cancer
- Registration Number
- NCT00900367
- Lead Sponsor
- Brigham and Women's Hospital
- Brief Summary
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about nutrition-related changes that identify biomarkers related to cancer. It may also help doctors predict a woman's risk of developing breast cancer.
PURPOSE: This laboratory study is looking at nutrition-related biomarkers in predicting breast cancer risk in women.
- Detailed Description
OBJECTIVES:
* To complete characterization of metabolic serotypes based on the metabolome, and to adapt these profiles for human epidemiological studies.
* To determine the extent to which metabolic profiles that are reflective of or independent of long-term caloric intake predict breast cancer risk in nested case-control studies.
* To identify critical serum metabolites.
OUTLINE: Laboratory studies, including metabolome profiling by high performance liquid chromatography; and small molecule identification by mass spectroscopy, are performed on previously collected blood samples.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- Female
- Target Recruitment
- 1500
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Utility of metabolome profiles in predicting relative risk of developing breast cancer ongoing Utility of rat metabolome profiles for human epidemiological studies ongoing Generation of metabolome profiles that reflect nutritional status ongoing Identification of critical serum metabolites ongoing
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Dana-Farber/Brigham and Women's Cancer Center
🇺🇸Boston, Massachusetts, United States