Nutrition Modulated Metabolism as a Disease Risk Factor
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 1,500
- 试验地点
- 1
- 主要终点
- Utility of metabolome profiles in predicting relative risk of developing breast cancer
研究概览
简要总结
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about nutrition-related changes that identify biomarkers related to cancer. It may also help doctors predict a woman's risk of developing breast cancer.
PURPOSE: This laboratory study is looking at nutrition-related biomarkers in predicting breast cancer risk in women.
详细描述
OBJECTIVES:
- To complete characterization of metabolic serotypes based on the metabolome, and to adapt these profiles for human epidemiological studies.
- To determine the extent to which metabolic profiles that are reflective of or independent of long-term caloric intake predict breast cancer risk in nested case-control studies.
- To identify critical serum metabolites.
OUTLINE: Laboratory studies, including metabolome profiling by high performance liquid chromatography; and small molecule identification by mass spectroscopy, are performed on previously collected blood samples.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- — 至 120 Years（Child, Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Utility of metabolome profiles in predicting relative risk of developing breast cancer
时间窗: ongoing
Utility of rat metabolome profiles for human epidemiological studies
时间窗: ongoing
Generation of metabolome profiles that reflect nutritional status
时间窗: ongoing
Identification of critical serum metabolites
时间窗: ongoing
次要结局
未报告次要终点
研究者
Bruce Kristal
Associate Professor
Brigham and Women's Hospital