Nutrition Modulated Metabolism as a Disease Risk Factor
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Breast Cancer
- Sponsor
- Brigham and Women's Hospital
- Enrollment
- 1500
- Locations
- 1
- Primary Endpoint
- Utility of metabolome profiles in predicting relative risk of developing breast cancer
- Status
- Active, not recruiting
- Last Updated
- 6 years ago
Overview
Brief Summary
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about nutrition-related changes that identify biomarkers related to cancer. It may also help doctors predict a woman's risk of developing breast cancer.
PURPOSE: This laboratory study is looking at nutrition-related biomarkers in predicting breast cancer risk in women.
Detailed Description
OBJECTIVES: * To complete characterization of metabolic serotypes based on the metabolome, and to adapt these profiles for human epidemiological studies. * To determine the extent to which metabolic profiles that are reflective of or independent of long-term caloric intake predict breast cancer risk in nested case-control studies. * To identify critical serum metabolites. OUTLINE: Laboratory studies, including metabolome profiling by high performance liquid chromatography; and small molecule identification by mass spectroscopy, are performed on previously collected blood samples.
Investigators
Bruce Kristal
Associate Professor
Brigham and Women's Hospital
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Utility of metabolome profiles in predicting relative risk of developing breast cancer
Time Frame: ongoing
Utility of rat metabolome profiles for human epidemiological studies
Time Frame: ongoing
Generation of metabolome profiles that reflect nutritional status
Time Frame: ongoing
Identification of critical serum metabolites
Time Frame: ongoing