A Comparative Randomised Controlled Trial of Granisetron vs Ondansetron in Prevention of Chemotherapy Induced Nausea and Vomiting â?? An Open Label Parallel Group Study

Dr Nenavath Vinay0 个研究点目标入组 94 人开始时间: 待定最近更新: 2021年11月24日

试验速览

暂无简介。

•Inclusion Criteria:
•1.Patients aged between 20 yrs and 65 yrs of both sexes at the time when they are giving consent
•2.Diagnosed as cancer patients by the Medical Oncologist are only taken for the study
•3.Be naÃ¯ve to chemotherapy or been treated with single cycle of Chemotherapy with Moderate Emetogenicity and Low emetogenicity Chemotherapeutic agents
•4.Patient who were scheduled to receive chemotherapy with any dose of Moderate or Low emetogenic potential chemotherapeutic agents except Carboplatin

•Exclusion Criteria:
•1.Known Allergic to Ondansetron or Granisetron or Dexamethasone
•2.Patients who are too sick to give informed consent
•3.Patients having baseline prolong QTc interval with arrythmias and conduction defects
•4.Patients with Severe and uncontrollable complications
•5.Patients with abnormal Serum levels of Potassium, Calcium and Magnesium will be excluded
•6.Patients with Metastasis to brain which are symptomatic
•7.Patients with Seizure disorder requiring anticonvulsant medication unless clinically stable and free of seizure activity
•8.Symptomatic or invasive procedure indicated ascites or pleural effusion
•9.Patients having either gastric outlet stenosis or intestinal obstruction
•10.Patients having Ongoing emesis or greater nausea
•11.Liver failure and Kidney failure patients
•12.Pregnant women and Lactating mothers
•13.Any male or female who is not willing to practice adequate contraceptive measures during the study period
•14.Subject who is currently enrolled in another investigational drug study

发起方

Dr Nenavath Vinay