NCT03542253Unknown不适用
Combined Diagnosis of CT and Exosome in Early Lung Cancer
Second Affiliated Hospital of Soochow University0 个研究点目标入组 80 人开始时间: 2018年5月20日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 80
- 主要终点
- exosome in cancer tissue and para cancerous tissue
研究概览
简要总结
This experiment has now collected 50 cases, all through CT chest scans and blood exosome detection. Twenty-two patients underwent surgical treatment and 14 tissue specimens were examined for cancer and paracancerous tissue exosomesWe found that exosomal micor-A was highly expressed in early stage lung cancer tissues and was significantly higher than paracancerous tissues. The micor-A in the adjacent tissues was significantly higher than that in peripheral blood exosomes
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Other
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •At least 18 years of age, male or female;
- •No patients with acute disease;
- •Chest or LDCT examination for the first time found 5-30mm pulmonary nodule patients, and ruled out disseminated tuberculosis;
- •Past pulmonary nodes Festival failed to diagnose.
- •Have not received a history of surgical treatment of the lungs;
- •Patients who have not received targeted drugs, biological treatments, immunosuppressive agents, and modulators;
- •No organ transplants;
- •Signed informed consent before undergoing clinical studies Consent and adherence to the research protocol.
排除标准
- •Pulmonary nodules have been treated surgically (considering that surgery has been performed to interfere with the study);
- •History of organ transplants such as lung transplantation (consider the use of allogeneic genes and immunosuppressive agents);
- •Pregnancy or lactation (consider Failure to perform regular CT follow-up and fetal component effects.
- •Known HIV-positive or only AIDS-related diseases (taking into account interference with the use of immune drugs);
- •Being targeted drugs, immunosuppressive agents, immunomodulators, biotherapies Patients;
- •Active pulmonary tuberculosis (consider infectious and referral missing factors);
- •RNA-like viral infections: such as SARS, HIV, hepatitis virus (except for hepatitis B, the other four are all RNA viruses), influenza virus, Bird flu virus, H5N1, Ebola, measles, etc.
- •Various blood system diseases such as leukemia, lymphoma, aplastic anemia, myelodysplastic syndrome, anemia, hemolysis, hemophilia, DIC, etc.
- •Recent history of blood transfusion (within 3~6 years) and potential for blood transfusion;
- •Patients with neurological disorders and mental disorders unable to cooperate;
- •Emergency treatment for acute and severe diseases;
- •No Willing to sign a written informed consent and follow the study protocol before they are willing to conduct clinical research;
- •The presence of the patient may interfere with any psychological, family, social or geography conditions that obey the requirements of the research protocol or the follow-up procedure. Discuss these conditions with the patient before entering the study.
结局指标
主要结局
exosome in cancer tissue and para cancerous tissue
时间窗: one year
exosomal micor-A was highly expressed in early stage lung cancer tissues
次要结局
未报告次要终点
研究者
gongjianping
Combined diagnosis of CT and exosome in early lung cancer
Second Affiliated Hospital of Soochow University
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