Detection of Bone Marrow Metastases With Magnetic Resonance Imaging
试验速览
- 阶段
- 不适用
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- specificity
研究概览
简要总结
The goal of this clinical trial is to study the value and feasibility of magnetic resonance imaging in detection of bone marrow metastases
详细描述
The patient was diagnosed as bone metastasis by pathology. CT showed no bone marrow biopsy site metastasis (anterior iliac spine or posterior iliac spine). After functional magnetic resonance examination, bone marrow biopsy was performed. Functional magnetic resonance imaging includes conventional SE sequence, T2W SPAIR, e-THRIVE,DWI,IVIM. With bone marrow biopsy as the gold standard, the sensitivity, specificity and coincidence rate of functional MRI in the diagnosis of bone marrow metastasis were evaluated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with malignant tumors (solid tumors or hematological malignancies) were definitely diagnosed by pathology or cytology.
- •patients with bone metastases confirmed by more than two imaging examinations.
- •ECOG score: 0-
- •The expected survival time is more than 3 months.
- •Sign the informed consent.
排除标准
- •Imaging findings suggest that bone metastases are present at the bone marrow puncture site.
- •The patient refused bone marrow puncture.
- •Puncture site with infection.
- •Severe coagulation dysfunction.
- •There are implanted instruments in the body, so magnetic resonance imaging can not be performed.
结局指标
主要结局
specificity
时间窗: through study completion, an average of 1 year
With bone marrow biopsy as the gold standard, the specificity of functional MRI in the diagnosis of bone marrow metastasis
sensitivity
时间窗: through study completion, an average of 1 year
With bone marrow biopsy as the gold standard, the sensitivity of functional MRI in the diagnosis of bone marrow metastasis
次要结局
未报告次要终点
研究者
Zhao Hui
professor
Shanghai 6th People's Hospital