Detection of Bone Marrow Metastases With Magnetic Resonance Imaging
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Bone Marrow Metastases
- Sponsor
- Shanghai 6th People's Hospital
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- specificity
- Last Updated
- 4 years ago
Overview
Brief Summary
The goal of this clinical trial is to study the value and feasibility of magnetic resonance imaging in detection of bone marrow metastases
Detailed Description
The patient was diagnosed as bone metastasis by pathology. CT showed no bone marrow biopsy site metastasis (anterior iliac spine or posterior iliac spine). After functional magnetic resonance examination, bone marrow biopsy was performed. Functional magnetic resonance imaging includes conventional SE sequence, T2W SPAIR, e-THRIVE,DWI,IVIM. With bone marrow biopsy as the gold standard, the sensitivity, specificity and coincidence rate of functional MRI in the diagnosis of bone marrow metastasis were evaluated.
Investigators
Zhao Hui
professor
Shanghai 6th People's Hospital
Eligibility Criteria
Inclusion Criteria
- •Patients with malignant tumors (solid tumors or hematological malignancies) were definitely diagnosed by pathology or cytology.
- •patients with bone metastases confirmed by more than two imaging examinations.
- •ECOG score: 0-
- •The expected survival time is more than 3 months.
- •Sign the informed consent.
Exclusion Criteria
- •Imaging findings suggest that bone metastases are present at the bone marrow puncture site.
- •The patient refused bone marrow puncture.
- •Puncture site with infection.
- •Severe coagulation dysfunction.
- •There are implanted instruments in the body, so magnetic resonance imaging can not be performed.
Outcomes
Primary Outcomes
specificity
Time Frame: through study completion, an average of 1 year
With bone marrow biopsy as the gold standard, the specificity of functional MRI in the diagnosis of bone marrow metastasis
sensitivity
Time Frame: through study completion, an average of 1 year
With bone marrow biopsy as the gold standard, the sensitivity of functional MRI in the diagnosis of bone marrow metastasis