A Randomized Controlled Trial on the Impact of Early Application of CRRT on the Outcomes of Burn Patients With Early Phase of Sepsis
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Changes in serum cytokine concentrations and clearance
研究概览
简要总结
The purpose of this study is to determine if early application of CRRT will result in an improvement of clinical outcomes of burn patients during the early phase of sepsis
详细描述
The impact of Continuous Renal Replacement Therapy (CRRT) on the outcomes of patients with sepsis is controversial, and there is no consensus for the timing and dose of CRRT may improve the outcomes. The purpose of this prospective randomized study is to assess the effect of different CRRT intensity (25ml/kg/h or 50ml/kg/h) on the outcomes of burn patients with early phase of sepsis
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with documented sepsis
- •clinically identified focus of infection associated with at least 2 SIRS -criteria and one or more sepsis-induced organ failures within the 24 hours -prior to inclusion
- •age 18 to 70 years
- •severe burned patients with 50% < TBSA < 85%
排除标准
- •cirrhosis child class C
- •too high APACHE II & SOFA score at admission
- •age over 70 years
- •were presence of a malignant tumor, chronic renal insufficiency (serum creatinine > 133 µmol/L), moribund state, receiving immunosuppressive therapy or receiving any kind of renal replacement therapy before randomization
研究组 & 干预措施
Control group
干预措施: Continuous Renal Replacement Therapy (Procedure)
early HV-crrt
干预措施: Continuous Renal Replacement Therapy (Procedure)
结局指标
主要结局
Changes in serum cytokine concentrations and clearance
时间窗: 96 hours
0, 6, 12 , 24, 48, 96 hours post CRRT
次要结局
- 28 and 90 days survival(90 days)
研究者
Zhiqiang Yuan
Associate Professor
Southwest Hospital, China