The Impact of Continuous Renal Replacement Therapy on the Outcomes of Burn Patients With Early Phase of Sepsis

Not Applicable

• Conditions: Sepsis; Burns
• Interventions: Procedure: Continuous Renal Replacement Therapy

• Registration Number: NCT01501097
• Lead Sponsor: Southwest Hospital, China

Brief Summary

The purpose of this study is to determine if early application of CRRT will result in an improvement of clinical outcomes of burn patients during the early phase of sepsis

Detailed Description

The impact of Continuous Renal Replacement Therapy (CRRT) on the outcomes of patients with sepsis is controversial, and there is no consensus for the timing and dose of CRRT may improve the outcomes. The purpose of this prospective randomized study is to assess the effect of different CRRT intensity (25ml/kg/h or 50ml/kg/h) on the outcomes of burn patients with early phase of sepsis

Study Timeline

• Status Verified: 2011-12
• Study Start: 2011-12
• Study First Submitted: 2011-12-20
• Study First Submitted QC: 2011-12-25
• Last Update Submitted: 2011-12-28
• Study First Posted: 2011-12-29
• Last Update Posted: 2011-12-30
• Primary Completion: 2013-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• patients with documented sepsis
• clinically identified focus of infection associated with at least 2 SIRS -criteria and one or more sepsis-induced organ failures within the 24 hours -prior to inclusion
• age 18 to 70 years
• severe burned patients with 50% < TBSA < 85%

Exclusion Criteria

• cirrhosis child class C
• too high APACHE II & SOFA score at admission
• age over 70 years
• were presence of a malignant tumor, chronic renal insufficiency (serum creatinine > 133 µmol/L), moribund state, receiving immunosuppressive therapy or receiving any kind of renal replacement therapy before randomization

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
early HV-crrt	Continuous Renal Replacement Therapy	-
Control group	Continuous Renal Replacement Therapy	-

Primary Outcome Measures

Name	Time	Method
Changes in serum cytokine concentrations and clearance	96 hours	0, 6, 12 , 24, 48, 96 hours post CRRT

Secondary Outcome Measures

Name	Time	Method
28 and 90 days survival	90 days

Trial Locations

Locations (1)

Southwest Hospital; 🇨🇳 Chongqing, Chongqing, China