How does the usage of steroids affect the postoperative prognosis of patients undergoing surgery for intradural spinal cord tumors?
- Conditions
- Neoplasms
- Registration Number
- KCT0009467
- Lead Sponsor
- Asan Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 56
(1) Adults aged 19 years and above
(2) Patients diagnosed with neurofibroma or meningioma within the thoracic spinal cord
(3) Patients capable of walking with a muscle strength of 3 or higher on the Medical Research Council (MRC) scale for lower limbs
(4) Patients willing to participate in the study, adhere to treatment and procedures, and visit the hospital for all follow-up evaluations
(5) Patients who have received explanations regarding the purpose, methods, and effects of the study and have voluntarily signed the informed consent form
(1) Patients who are either under 18 years of age or 66 years of age and older
(2) Patients deemed by the investigator to be ineligible for spinal surgery under general anesthesia due to significant cardiovascular, pulmonary, hepatic, or renal dysfunction
(3) Patients with diabetes mellitus
(4) Patients with gastrointestinal disorders including gastritis and gastric ulcers
(5) Patients with hypersensitivity reactions or adverse effects to steroids
(6) Patients with infections in joint spaces, bursae, tendon sheaths, or around tendons
(7) Patients receiving live bacterial vaccines
(8) Patients with herpes simplex, herpes zoster, or chickenpox
(9) Patients with infections where effective antimicrobial therapy is not available or systemic fungal infections
(10) Patients receiving immunosuppressive therapy
(11) Patients requiring reoperation due to recurrence of existing tumors
(12) Patients diagnosed with neurofibromatosis
(13) Patients with neurofibromas showing a dumbbell tumor pattern invading the neural foramina
(14) Pregnant or lactating women
(15) Patients with cognitive impairment making communication with medical staff and completion of surveys difficult
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Assessment of pain severity in patients using the Korean Neuropathic Pain Questionnaire (KNPQ)
- Secondary Outcome Measures
Name Time Method eurological evaluation of patients: mJOA (modified Japanese orthopedic association) score for thoracic myelopathy, Modified McCormick scale, ASIA scale (American Spinal Injury Association) ;Assessment of pain severity in patients: Pain DETECT Questionnaire, SF-MPQ (Short-form McGill Pain Questionnaire), LANSS (Leeds Assessment of Neuropathic Symptoms and Signs) pain scale;Assessment of quality of life in patients: EQ-5D (EuroQol-5Dimention), SF-36 (Short Form-36);Evaluation of activities of daily living in patients: SCIM III (Spinal Cord Independence Measure III);Complete resection of tumor post-surgery through magnetic resonance imaging (MRI) scans;Presence of spinal cord signal change through magnetic resonance imaging (MRI) scans;Adverse event