Prospective Memory Imaging

Not Applicable

• Conditions: Alzheimer Disease
• Interventions: Behavioral: Memory assessment; Other: Structural MRI; Other: Functional MRI; Other: Virtual reality / Memory assessment

• Registration Number: NCT01638884
• Lead Sponsor: University Hospital, Caen

Brief Summary

The purpose of this study is to investigate prospective merory (memory of intentions) in healthy controls and in aMCI (amnestic Mild Cognitive Impairment) and AD (Alzheimer Disease) patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-09
• Study First Submitted: 2012-07-10
• Study First Submitted QC: 2012-07-10
• Study First Posted: 2012-07-12
• Status Verified: 2014-04
• Last Update Submitted: 2014-04-08
• Last Update Posted: 2014-04-09
• Primary Completion: 2015-06
• Study Completion: 2015-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 118

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
Young Healthy Subjects	Memory assessment	-
Young Healthy Subjects	Structural MRI	-
Young Healthy Subjects	Functional MRI	-
Young Healthy Subjects	Virtual reality / Memory assessment	-
Middle age Healthy Subjects	Memory assessment	-
Middle age Healthy Subjects	Structural MRI	-
Middle age Healthy Subjects	Functional MRI	-
Middle age Healthy Subjects	Virtual reality / Memory assessment	-
Elderly Healthy Subjects	Memory assessment	-
Elderly Healthy Subjects	Structural MRI	-
Elderly Healthy Subjects	Functional MRI	-
Elderly Healthy Subjects	Virtual reality / Memory assessment	-
Mild Cognitive Impairment patients	Memory assessment	-
Mild Cognitive Impairment patients	Structural MRI	-
Mild Cognitive Impairment patients	Functional MRI	-
Alzheimer Disease patients	Virtual reality / Memory assessment	-
Mild Cognitive Impairment patients	Virtual reality / Memory assessment	-
Alzheimer Disease patients	Memory assessment	-
Alzheimer Disease patients	Structural MRI	-
Alzheimer Disease patients	Functional MRI	-

Primary Outcome Measures

Name	Time	Method
Rate of volume change of whole brain and other structural MRI measures	1 Month
Cerebral regions implicated in prospective memory observed by functional MRI	1 Month
Episodic memory as measured by Cognitive Tests	18 Months
Virtual reality evaluation of prospective memory	1 Month
Group differences for each imaging and neuropsychological measurement	1 Month

Trial Locations

Locations (3)

GIP Cyceron; 🇫🇷 Caen, Calvados, France

MRSH - University of Caen; 🇫🇷 Caen, Calvados, France

University Hospital Côte de Nacre; 🇫🇷 Caen, France