Effectiveness of Computerized Cognitive Training in the Elderly With Cognitive Impairment

Not Applicable

Completed

• Conditions: Mild Cognitive Impairment
• Interventions: Behavioral: Computerized Cognitive Training Apparatus

• Registration Number: NCT02480738
• Lead Sponsor: Seoul National University Bundang Hospital

Brief Summary

This study is to investigate the effectiveness of computerized cognitive training, and corresponding neural substrates through multimodal neuroimaging assessment, in the elderly with normal cognition, subjective cognitive impairment, and mild cognitive impairment.

Detailed Description

Computerized cognitive training has the advantage of easy accessibility for community-dwelling elderly. It can be much cheaper than traditional neuropsychological training methods, which require trained neuropsychologists. Furthermore, it may be more fun and easier to be optimized to an individual patients' cognitive status than other traditional methods.

Clinical efficacy of these kinds of cognitive training applications has been validated through several studies. A recent systematic review reported that the domains of working memory, executive function, and processing speed benefited the most by classic computerized cognitive training tasks, and that these benefits were comparable with traditional cognitive training methods. Apart from neuropsychological data, neuroimaging studies focusing on the effectiveness of computerized cognitive training are scant.

There have been no previous studies investigating the possible neural substrates of computerized cognitive training using multimodal neuroimaging modalities simultaneously. Thus, we aimed to investigate the effectiveness of computerized cognitive training and corresponding neural substrates in subjects with mild cognitive impairment, subjective memory impairment, and normal controls through a multimodal approach.

Study Timeline

• Study Start: 2012-06
• Primary Completion: 2013-04
• Study Completion: 2013-07
• Study First Submitted: 2015-06-22
• Study First Submitted QC: 2015-06-23
• Study First Posted: 2015-06-24
• Status Verified: 2019-05
• Last Update Submitted: 2019-05-16
• Last Update Posted: 2019-05-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 26

Inclusion Criteria

• Ages >50 to ≤70
• Years of education ≥ 6 years
• No physical barrier preventing the dominant hand from using the computer mouse

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Exclusion Criteria

• Subjects who had any structural lesions or psychiatric disorders that explained the memory deficits
• Subjects had to be able to undergo pre- and post-training evaluations such as electroencephalography (EEG), FDG-PET, and magnetic resonance imaging (MRI)
• Subjects who had scalp lesions, severe back pain, or claustrophobia that precluded pre- and post-training evaluations.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Normal controls	Computerized Cognitive Training Apparatus	Intervention: Computerized Cognitive Training Apparatus
Mild cognitive impairment	Computerized Cognitive Training Apparatus	Intervention: Computerized Cognitive Training Apparatus
Subjective cognitive impairment	Computerized Cognitive Training Apparatus	Intervention: Computerized Cognitive Training Apparatus

Primary Outcome Measures

Name	Time	Method
Clinical improvement in the follow-up neuropsychological tests	12 weeks	changes in memory and frontal domain subscores between the baseline and follow-up

Secondary Outcome Measures

Name	Time	Method
White matter integrities changes between baseline and follow-up diffusion tensor imaging	12 weeks	tract-based spatial statistics using fsl software
local activation pattern changes between baseline and follow-up Fludeoxyglucose PET	12 weeks	local activation pattern analysis using SPM
Cortical thickness changes between baseline and follow-up volumetric MRI	12 weeks	surface-based morphometry using freesurfer software
Spectral ratio changes between baseline and follow-up EEG	12 weeks	EEG spectral ratio analysis