Contributing Factors to Anterior Resection Syndrome and Its Impact on Quality of Life: A Retrospective Cohort Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Low Anterior Resection Syndrome
- Sponsor
- University of Malta
- Enrollment
- 179
- Locations
- 1
- Primary Endpoint
- LARS incidence
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
This study adds to the understanding of the contributing factors leading to LARS, the long term effects of this syndrome post-operatively and its impact on quality of life.
Investigators
Svetlana Doris Brincat
Surgical trainee
University of Malta
Eligibility Criteria
Inclusion Criteria
- •All adult patients \>18 years, under the care of all surgical firms at Mater Dei Hospital, who had undergone anterior resection for rectal cancer between January 2014 and December 2016
Exclusion Criteria
- •colorectal cancer (\>15cm) from anal verge
- •permanent stoma
- •known disseminated or recurrent disease,
- •patient without restitution of bowel continuity after 1 year
Outcomes
Primary Outcomes
LARS incidence
Time Frame: 1 year
Incidence of LARS in patients who had anterior resection
Life
Time Frame: 1 year
The association between LARS and quality of life was assessed.
Risk factors
Time Frame: 1 year
Variable factors which might have contributed to LARS were the following: * Age * Gender * Diabetes mellitus * Pathological stage * MRI stage * Distance from anal verge * Surgical technique * Preoperative radiotherapy * Preoperative chemotherapy * Postoperative radio/chemotherapy * Type of anastomosis * Presence of stoma * Interval from stoma reversal * Duration of follow-up