Protein turnover in the osteoarthritic knee; the impact of preoperative protein intake. - KneeT

niversiteit Maastricht0 个研究点目标入组 24 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

暂无简介。

•- Written informed consent
•- Male and female patients scheduled for total knee arthroplasty
•- BMI between 18.5-35 kg/m2
•- Age >18 years
•- Mentally competent, as judged by the treating physician
•- Functioning gastrointestinal tract, eligible for oral protein supplementation

•- Corticosteroid injections less than 3 months prior to participation
•- Any medications know to affect protein metabolism (i.e. systemic
•corticosteroids or prescription strength acne medications)
•- Lactose intolerance
•- Insulineafhankelijke diabetes mellitus
•- Alcohol abuse
•- Rheumatoid arthritis
•- Peripheral artery disease Fontaine III or IV
•- COPD GOLD III or IV
•- Pheynylketonuria
•- Surgical intervention to the knee in the past four weeks
•- Total parenteral nutrition at day of surgery
•- Neoadjuvant chemotherapy or radiotherapy
•- GFR <20 mL/min/1.73 m2
•- Osteoarthritis of the knee secondary to septic arthritis, osteonecrosis,
•fracture, OD, or malignant processes
•- Collagen disorders, e.g. Marfan and Ehler-Danlos
•- Any other medical condition that may interfere with the safety of the
•subjects or the outcome parameters, in the investigators judgement
•- Investigator*s uncertainty about the willingness or ability of the subject to
•comply with the protocol instructions
•- Participation in any other studies involving investigational or marketed
•products concomitantly or within two weeks prior to entry into the study

发起方