Evaluation of the Association Between Electroencephalographic Changes and Hormonal Response to Tracheal Intubation and Surgical Stimulation in Abdominal Surgery: a Prospective Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 52
- 试验地点
- 1
- 主要终点
- Association between band power changes in EEG and hormone respones caused by endotracheal intubation
研究概览
简要总结
This study aims to prospectively evaluate the relationship between changes in EEG and hormonal responses induced by endotracheal intubation and surgical incision following general anesthesia.
详细描述
This study aims to investigate the relationship between changes in EEG patterns and stress hormone levels in patients undergoing open abdominal surgery under general anesthesia when subjected to endotracheal intubation and surgical incision stimuli.
Hormone measurements (cortisol, ACTH) are taken at four time points: before endotracheal intubation (T1), one minute after intubation (T2), and one minute after surgical incision (T3). The investigators evaluate the correlation between hormone levels (cortisol, ACTH) and EEG band power changes (alpha, beta, delta) before and after endotracheal intubation and surgical incision.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •1) Patients scheduled to undergo open abdominal surgery under general anesthesia with endotracheal intubation.
- •2) Patients requiring invasive blood pressure monitoring during surgery
排除标准
- •1) Patients transferred to the intensive care unit after surgery
- •2) Surgery duration of less than one hour
- •3) Patients with neurological underlying conditions
- •4) Patients on chronic use of psychotropic medications and opioid drugs
- •5) Emergency surgery
结局指标
主要结局
Association between band power changes in EEG and hormone respones caused by endotracheal intubation
时间窗: from the start of anesthesia induction to one minute after endotracheal intubation
次要结局
- Association between band power changes in EEG and hormone respones caused by surgical incision(from the start of anesthesia induction to one minute after surgical incision)
研究者
Hyun-Kyu Yoon
Clinical assistant professor
Seoul National University Hospital