Relationship of uterine fibroids with thyroid problems and the gut microbes in huma
Not Applicable
- Conditions
- Health Condition 1: D25- Leiomyoma of uterus
- Registration Number
- CTRI/2020/11/029238
- Lead Sponsor
- Manipal Academy of Higher Education
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Group 1:
1.Premenopausal women with Uterine fibroids
2. Age group: 20 â?? 55 years
Group 2
1.Premenopausal women without Uterine fibroids
2.Age group: 20 â?? 55 years
For gut metabolite analysis:
Matching age and BMI
Exclusion Criteria
Group 1:
1.Malignancies
2.Currently pregnant
Group 2:
PCOS, heavy menstrual bleeding, endometriosis,adenomyosis
, Malignancies, Currently pregnant
For gut metabolite analysis:
1.Liver disease
2.Severe renal disease
3.Gastrointestinal diseases
4.Infectious diseases
5.History of major gastrointestinal surgery in the previous year
6.Patientsunderanyantibiotictreatment/probiotic supplement intake for the past 3 months
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum TSH levelTimepoint: December 2020 to June 2023
- Secondary Outcome Measures
Name Time Method 1.Estimation of fecal beta glucuronidase <br/ ><br>2. Estimation of fecal short chain fatty acids <br/ ><br>3. Estimation of fecal indole <br/ ><br>4.Questionnaire to assess quality of life and health related lifestyle of women with uterine fibroidsTimepoint: 1,2 and 3 outcomes will be done from December 2021 to June 2023 <br/ ><br>4- December 2020 to June 2023