Effects of Transcranial Electric Stimulation on Associative Memory Formation in Healthy Elderly Participants as Well as in Individuals With Memory Impairment
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 28
- 试验地点
- 1
- 主要终点
- Performance on immediate cued recall task
研究概览
简要总结
Previous studies showed that transcranial electric stimulation (tES) applied over the prefrontal cortex improves cognitive performance in healthy elderly adults as well as in patients suffering from mild cognitive impairment or early Alzheimer's disease. Therefore, tES methods might be a useful intervention tool for patients suffering from memory impairment in early terms of the disease.
The present study aims at establishing a connection between the stimulation-induced changes on associative memory performance and its underlying neurophysiological parameters. tES effects and their underlying mechanisms will be compared between healthy elderly controls and clinical study populations receiving either real or sham tES over the left ventrolateral prefrontal cortex during an associative memory task.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 60 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Written informed consent
- •Non-smokers
- •Right-handedness
- •Native German speakers or comparable level of fluency
- •Normal or corrected-to-normal vision
排除标准
- •Neurological or psychiatric condition (other than diagnosed cognitive impairment)
- •Past head injuries
- •Magnetizable implants
- •History of seizures
- •Current or life-time alcohol or drug abuse
- •Skin diseases
研究组 & 干预措施
Real tDCS
20 min of 2 mA real anodal transcranial direct current stimulation applied via 5x7 cm rubber electrode over the VLPFC (current density: 0.057 mA/cm2) and cathodal 10x10 rubber electrode over supraorbital region (current density: 0.02 mA/cm2). Additional ramp-up and ramp-down phase of 15 s at the beginning and the end of stimulation.
干预措施: real anodal transcranial direct current stimulation (Device)
Real tACS
20 min of 2 mA real transcranial alternating current stimulation in theta frequency applied via 5x7 cm and 10x10 cm rubber electrodes over the VLPFC (current density: 0.057 mA/cm2) and supraorbital region (current density: 0.02 mA/cm2). Additional ramp-up and ramp-down phase of 15 s at the beginning and the end of stimulation.
干预措施: real transcranial alternating current stimulation (Device)
Sham tES
30 s of 2 mA sham transcranial electric current stimulation applied via 5x7 cm and 10x10 cm rubber electrodes over the VLPFC (current density: 0.057 mA/cm2) and supraorbital region (current density: 0.02 mA/cm2). Additional ramp-up and ramp-down phase at beginning and end of stimulation lasting for 15 s. Electrodes remain attached to the participant's head for the duration of the encoding phase of the memory task.
干预措施: sham transcranial electric current stimulation (Device)
结局指标
主要结局
Performance on immediate cued recall task
时间窗: 20 min
Number of correct responses on retrieval task of previously learned associative memory items
Performance on delayed cued recall task
时间窗: 24 hours
Number of correct responses on retrieval task of previously learned associative memory items
次要结局
- task-dependent BOLD activity(20 min)
- resting-state BOLD activity(10 min)