Improving the safety and efficacy of anticoagulation therapy
Not Applicable
Completed
- Conditions
- AnticoagulationSubtopic: Blood (all Subtopics)Haematological DisordersTopic: BloodDisease: Non-malignant haematology
- Registration Number
- ISRCTN64826232
- Lead Sponsor
- ewcastle upon Tyne Hospitals NHS Foundation Trust (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 180
Inclusion Criteria
1. Long term warfarin therapy
2. Aged greater than or equal to 18 years
3. Male and female
Exclusion Criteria
1. Abnormal hepatic or renal function
2. Impairment of cognitive function
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Percent time within target INR (calculated by the method of interpolation) for the study period, measured at baseline and weeks 1, 2, 4, 8, 12, 16, 20 and 24 weeks.
- Secondary Outcome Measures
Name Time Method 1. Clinical events of major (defined as bleeding that led to loss of 2 units of blood over a 7 day period<br>2. Days attending anticoagulation clinic to monitor and achieve target International Normalised Ratio (INR)<br>3. Markers of lack of efficacy including recurrent thrombosis<br>4. The number of warfarin dose changes<br>5. Quality of life questionnaires recorded at baseline and repeated at the end of the study