Brain networks involved in essential tremor: elucidating tremor pathophysiology using EMG-fMRI - ET brain networks

niversitair Medisch Centrum Groningen0 个研究点目标入组 130 人开始时间: 待定最近更新: 2024年4月29日

适应症

试验速览

暂无简介。

•Healthy subjects:
•- subjectively healthy, including vision (after correction)
•- 18 years or older and as well as possible age-matched with patients
•- informed consent
•- righthanded according to the Annett Handedness scale
•ET patients:
•- ET according to the cirteria defined by the Tremor Investigation Group
•- using propranolol or primidone effectively (determined subjectively) and willing to stop this medication temporarily, or intention to start medication use
•- heriditary ET
•- informed consent
•- 18 years or older
•- righthanded acoording to the Annett Handedness scale
•- subjectively healthy (except for tremor), including vision (after correction)

•ET patients:
•- absent (Tremor Rating Scale (TRS) Part A 2 UE < 2) or atypical tremor when off medication, as confirmed by polymyography (tremor recording)
•- no measurable medication response
•- no medication response after wash-in in de novo ET patients
•General MR-related:
•- presence of metal implants
•- presence of electronic implants (eg heart pacemakers) en connections to electronic hardware (eg implanted electrodes)
•- claustrophobia
•- (possible) pregnancy
•General other:
•- MMSE < 27
•- reumatoid disorder of the wrist, or other non-ET related disorders that can hamper fluent movement of the wrist
•- use of medication/drugs that can influence taks performance

发起方