NL-OMON39415
Completed
Not Applicable
Brain networks involved in essential tremor: elucidating tremor pathophysiology using EMG-fMRI - ET brain networks
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- essential tremor
- Sponsor
- niversitair Medisch Centrum Groningen
- Enrollment
- 130
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Healthy subjects:
- •\- subjectively healthy, including vision (after correction)
- •\- 18 years or older and as well as possible age\-matched with patients
- •\- informed consent
- •\- righthanded according to the Annett Handedness scale
- •ET patients:
- •\- ET according to the cirteria defined by the Tremor Investigation Group
- •\- using propranolol or primidone effectively (determined subjectively) and willing to stop this medication temporarily, or intention to start medication use
- •\- heriditary ET
- •\- informed consent
Exclusion Criteria
- •ET patients:
- •\- absent (Tremor Rating Scale (TRS) Part A 2 UE \< 2\) or atypical tremor when off medication, as confirmed by polymyography (tremor recording)
- •\- no measurable medication response
- •\- no medication response after wash\-in in de novo ET patients
- •General MR\-related:
- •\- presence of metal implants
- •\- presence of electronic implants (eg heart pacemakers) en connections to electronic hardware (eg implanted electrodes)
- •\- claustrophobia
- •\- (possible) pregnancy
- •General other:
Outcomes
Primary Outcomes
Not specified
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