Comparison of the Effect of Matricaria Chamomilla Extract and Mefenamic Acid on intensity of premenstrual syndrome

Phase 3

• Conditions: premenstural syndrom.; Premenstrual tension syndrome

• Registration Number: IRCT201201258801N2
• Lead Sponsor: The international Branch of Shahid Beheshti University of Medical Siences and Health Services

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 90

Inclusion Criteria

Single students; 18-35 years old; With normal body mass index (19.8 -26) ; No smoking; Regular menstrual cycles( 21-35 days) ; No physical disease (digestive problems like ulcers, diabetes, seizure disorders, hypothyroidism and endometriosis, and ...)and no known mental illnes; At least 5 symptoms of premenstrual syndrome symptoms in a temporary form of DSMIV with necessarily one symptoms from first to fourth (1 - Markedly depressed, mood and feelings of hopelessness, 2 - Significant anxiety, tension, feelings of impatience and anxiety, 3- Significant mood instability, such as sudden sadness, 4 - Continuous and apparent anger or irritability or increased interpersonal conflicts); lack of depression based on the Beck Depression questionnaire ; no history of consumption of Certain drugs (hormones, vitamins, antidepressants, herbal medicines, aspirin, warfarin); No allergy to herbal medicines; no sad event such as death of close relatives and surgery in the past six months; Not being professional athlete. Exclusion criteria: Sensitivity to drugs; Incorrect use of capsules (two capsules daily, if not, the person is excluded); Married during the study; Having specific disease and to take medications during the study; Occurrence of a sad event such as death of close relatives and surgery; To exercise professionally.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The severity of physical symptoms of premenstrual syndrome. Timepoint: pre intervention, first month after intervention, second month after intervention. Method of measurement: Daily form of severity of premenstrual syndrome.;The severity of psychological symptoms of premenstrual syndrome. Timepoint: pre intervention, first month after intervention, second month after intervention. Method of measurement: Daily form of severity of premenstrual syndrome.;The severity of symptoms of premenstrual syndrome. Timepoint: pre intervention, first month after intervention, second month after intervention. Method of measurement: Daily form of severity of premenstrual syndrome.

Secondary Outcome Measures

Name	Time	Method
Side effects of chamomile. Timepoint: first month after intervention, second month after intervention. Method of measurement: Questionnaire of effects and side effects of medication.;Side effects of mefanamic acid capsule. Timepoint: first month after intervention, second month after intervention. Method of measurement: Questionnaire of effects and side effects of medication.